Relationship of testosterone ester chain length to half-life and solubility


When understanding the half-life of a testosterone derivative, we will propose that its half-life is related to the length of the ester to which it is linked, and the longer the length of the ester chain, the longer the half-life of the corresponding compound. The half-life of testosterone is very short, only a few hours, and the testosterone after the addition of ester has a longer half-life, avoiding the trouble of frequent administration.
The half-life of various testosterone esters
Test Acetate, C21H30O3, half-life for 3 days,
Test Propionate, C22H32O3, half-life 4.5 days,
Test Phenylpropionate, C28H36O3, half-life 4.5 days,
Test Isocaproate, C25H38O3, half-life, 9 days
Test Enanthate, C26H40O3, half-life 10.5 days
Test Cypionate, C27H40O3, half-life 12 days
Test Decanoate, C29H46O3, half-life for 15 days
Test undecanoate, C30H48O3, half-life 16.5 days
Extending the half-life is of great significance, so does the length of the ester chain only prolong the half-life?
It's not just that. The length of the attached ester chain also affects the solubility of the compound. Testosterone esters are essentially injected, and increased solubility increases the amount of active compounds contained in the per ml solution.
By testosterone acetate (TAce), testosterone propionate (TPro), testosterone phenylpropionate (TPhp), Experimentation with the solubility of testosterone isocaproate (TIso) has observed that the solubility is correlated with the half-life of the prodrug, so that the acetate with the shortest half-life has the lowest solubility and the isocaproate with the longest half-life has the highest solubility. The longest ester (isocaproate) is about four times more soluble.
In the experiment, although the phenylpropionate has six more carbon atoms than the propionate, the solubility is similar, so it can be noted that the important factor that increases the solubility is the length of the carbon chain, and the benzene ring does not lead to an increase in solubility.
The longer the ester chain, the higher the solubility of testosterone ester, and the higher the solubility is conducive to improving the content of active ingredients in the finished solution, which is conducive to the stability of the solution, convenient for drug administration, and also to the further preparation of the follow-up.
In experiments, of the six liquids used to dissolve testosterone esters, it was observed that castor oil could support the highest solubility without collapse (compound crystallization) and to a lesser extent MCT (for TAce, TPro, and TPhp), while also acting as a solvent. This is interesting because MCT is characterized by the lowest viscosity coefficient, while castor oil has the highest viscosity.
Therefore, the reasonable selection of testosterone ester and the corresponding solvent can increase the content of active ingredients in the unit dose, and facilitate the user to use testosterone ester better.

Chemical structure and function of testosterone


Testosterone is a naturally occurring male sex hormone in the human body. It is produced mainly in the testicles of men and in small amounts in the ovaries and adrenal glands of women. Testosterone is a steroid compound with a typical sterane core structure consisting of three carbon five-membered rings and one carbon four-membered ring. It has the formula C19H28O2 and belongs to the androstane family, specifically the 17-β-hydroxy-androstane-3-1 family.
The main chemical characteristics of testosterone
1. Two hydroxyl groups in the C-19 position. Through these two hydroxyl groups, testosterone can bind to testosterone receptors and exert biological activity.
2. A hydroxyl group at the C-17 position. By migrating the hydroxyl group, the effect of estrogen is generated.
3. Seven carbon-carbon double bonds. These carbon-carbon double bonds give the molecule a planar structure that facilitates binding to testosterone receptors.
The structure of testosterone determines its biological function
1. After binding to testosterone receptors, it activates related signal transduction pathways, promotes muscle protein synthesis, increases muscle size and strength, helps maintain bone density and prevent osteoporosis. At the same time, it regulates secondary sexual characteristics, such as stimulating sperm production, affecting sexual desire and sexual function.
2. The hydroxyl group of C-17 is easily reduced to a keto group, producing dihydrotestosterone (DHT), which has a higher affinity and can more effectively promote the development of secondary sexual characteristics and maintain sexual function.
3. Testosterone can be converted into estrogen through the displacement reaction and the removal of hydroxyl groups, which has the role of regulating secondary sex characteristics and promoting bone health.
4. Testosterone has a typical sterol structure, which is conducive to its passage through biofilms. And can bind SHBG and other binding proteins, convenient transport in the blood, play a role in various parts of the body.
5. Variations in the structure of testosterone can produce different derivatives or analogues with different biological effects and pharmacokinetic properties, playing a huge medical role.
In summary, the chemical structure of testosterone determines its multiple biological effects. From the chemical structure, we can know what role it may have. Through the study of its chemical structure, biologists can find and synthesize a variety of testosterone derivatives, which play different roles in different fields and provide new treatments for health and disease.

The Discovery and derivation of testosterone


The discovery and research of testosterone and its derivatives is of great significance, which opens the door of modern hormonology and greatly promotes the development of endocrinology, reproductive medicine and biology.
The discovery of testosterone
In the late 19th century, scientists studying the effects of castration on animals noticed that castrated animals lacked certain masculine traits and were associated with decreased sexual function. In 1889, French physiologists experimented by injecting themselves with animal testicle extracts and reported various positive effects, sparking interest in the potential role of testicular secretions. In the mid-19th century, German physiologists conducted extensive research on testicular function and transplantation. His experiments with roosters have shown that testicular tissue transplants can restore the second trait. This is further evidence of the existence of a substance that determines male sexuality.
However, the chemical structure of testicular secretions has not been isolated and identified. It was not until 1935 that Dutch endocrinologists successfully isolated and purified the hormone testosterone from bull testicles and named it testosterone. This is an important milestone in the understanding of male sex hormones. In this process, the structure of testosterone was determined to be 4-androsten-17β-olone, molecular formula C19H28O2, molecular weight 288.4.
By the 1940s to the 1970s, the physiological effects and mechanisms of testosterone were gradually studied clearly, including its transformation metabolism in vivo, and the binding effect with receptors. This laid the foundation for the clinical application of testosterone.
Synthetic testosterone
After successfully isolating testosterone, scientists began researching ways to synthesize the hormone. Since then, many scientists have successfully synthesized testosterone, including extracting sterols from plant extracts and converting them into testosterone, or directly synthesizing testosterone using chemical reactions.
A derivative of testosterone
With the development of modern biotechnology, scientists have in-depth research on testosterone, found and synthesized a variety of different testosterone derivatives,
Including oral testosterone, different ester testosterone, steroids, etc., have promoted the wide application of testosterone in various medical fields.
Testosterone plays a vital role in all aspects of male physiology, including sexual development, muscle growth, bone density, and red blood cell production. It is also used to treat conditions such as hypogonadism and certain types of breast cancer.

The production of testosterone in men and women


Testosterone is a male hormone, however, in addition to being produced by men, women also produce testosterone. How is testosterone produced in men and women?
Testosterone production in men
In men, testosterone is produced mainly by the testicles. Its secretion is regulated by the hypothalamic-pituitary-testicular axis (HPGA).
The hypothalamus secretes gonadotropin-releasing hormone (GnRH) to stimulate the anterior pituitary gland to secrete gonadotropins (LH and FSH). LH mainly stimulates testicular secretion of testosterone,FSH mainly promotes the development of testicular endosperm cells and the secretion of antidiuretic hormone.
LH acts on the LH receptor of Leydig cell membrane of testis to promote the synthesis and secretion of testosterone. The synthesized testosterone is mainly released into the blood, and a small part is released into the spermatogenic tubules and other tissues.
High levels of testosterone in the blood can stimulate the hypothalamus and pituitary gland to produce negative feedback through the blood barrier, inhibit the secretion of GnRH, LH and FSH, reduce the synthesis and secretion of testosterone, and complete the negative feedback regulation of the endocrine axis.
In addition to the secretion of male testosterone is mainly regulated by HPGA, the adrenal cortex can synthesize a small amount of testosterone, the liver also has the potential to synthesize testosterone, adipose tissue can also convert androstentrione into a very small amount of testosterone, other tissues such as skin, gastrointestinal tract, etc., can synthesize a very small amount of testosterone, but the contribution is very small. Although there are many tissues that have the ability to synthesize testosterone and play a certain compensatory role when testicular function is impaired, it is difficult to rely on these tissues alone to meet the testosterone needs of men, so testosterone replacement therapy is often required in cases of testicular function impairment.
Testosterone production in women
The level of testosterone in women is about 1/10 of that of men, and it is mainly secreted by the ovaries and adrenal glands, and its production process is different from that of men.
The ovaries can produce a small amount of testosterone, and ovarian removal surgery can reduce a woman's testosterone levels by about 25-30%.
The adrenal glands can also synthesize testosterone, accounting for about 25% of a woman's testosterone. Adrenal disease or surgery can affect testosterone synthesis.
Women's testes can also produce small amounts of testosterone. Aromatase in adipose tissue also has the function of converting androstenedione to testosterone, but contributes less.
Although women also secrete testosterone, but the level is lower, mainly as a biosynthetic precursor of estrogen, and is involved in the formation and maintenance of female secondary sexual characteristics. The excess testosterone still needs to be cleared by metabolism in the body. Although testosterone levels are lower in women, women are more sensitive to the hormone testosterone.

How does triiodothyronine T3 improve the overall basal metabolism of bodybuilders?


The thyroid hormone T3(triiodothyronine) improves overall basal metabolism and heat production, increasing the body's oxygen and energy expenditure. How does T3 improve overall basal metabolism?
What is basal metabolism?
Basal metabolism, also known as basal metabolic rate (BMR), is the minimum caloric requirement required to maintain a resting individual's life. It represents the energy expenditure necessary to maintain basic physiological processes such as respiration, circulation, cell maintenance and the maintenance of body temperature.
Why improve your basal metabolism?
In general, people with a high basal metabolic rate tend to burn more calories when at rest, which helps with easier weight control and helps prevent weight gain.
People with a lot of muscle mass tend to have a higher basal metabolic rate because muscle requires more energy to maintain compared to fat.
How does T3 improve basal metabolism?
The thyroid hormone T3 acts on most tissues in the body, enhancing their function and metabolism.
Acts on proteins: T3 affects cell metabolism by affecting gene expression and protein synthesis. It regulates the metabolism of carbohydrates, proteins and promotes the utilization of nutrients to produce energy.
Increased glucose uptake: T3 enhances glucose metabolism and promotes glucose transport to cells, primarily in muscle and adipose tissue. It enhances the activity of glucose transporters and promotes the uptake of glucose from the blood into cells.
Enhances glycolysis: T3 increases the activity of enzymes involved in glycolysis, resulting in an increase in energy (in the form of ATP) produced by glucose.
Increased glycogen breakdown: Glycogen is the glucose stored in the liver and muscles. T3 promotes the release of this glucose into the blood, providing a direct source of energy.
Increased lipid metabolism: T3 stimulates cholesterol breakdown and increases the number of LDL receptors, thereby increasing the rate of fat decomposition.

Bone health with sex hormones androgen and estrogen


For bodybuilders, muscle gain is very important, as is the associated bone health. Is bone health related to the sex hormone androgens or estrogen?
Bone health with Androgens
Testosterone is the main male hormone that promotes bone formation and maintenance. A lack of testosterone can damage bones and increase the risk of osteoporosis.
Androgen can increase the level of extracellular endogenous ribonucleic acid and increase the activity and proliferation ability of bone cells.
Testosterone can inhibit the activity of bone resorption cells and reduce the destruction of bone.
Androgens also increase calcium absorption, which helps maintain bone mass.
Estrogen with Bone Health
Estrogen can inhibit the activity of bone cells and reduce the destruction of bone.
Estrogen can increase calcium absorption and promote bone maintenance.
Estrogen deficiency increases the activity of bone eating cells, leading to bone loss.
Menopause leads to a lack of estrogen in women and is the period when women are most prone to fractures.
Androgens and Estrogen with Bone Health
Androgens maintain bone health mainly by promoting bone production, while estrogen achieves its effect mainly by inhibiting bone destruction. When androgens and estrogens work together, they can improve the absorption and utilization of calcium and maintain the dynamic balance of bone health.
In fact, both estrogen and androgens are present together in both men and women.
In men, testosterone interacts with 5AR to produce estrogen. In women, the ovaries and adrenal glands produce small amounts of androgens.
In postmenopausal women, when estrogen levels drop, this part of the androgen is converted to estrogen, which helps maintain bone health.
Whether it is androgen or estrogen, lower than normal levels can affect bone health. With age, sex hormone levels decrease, and when necessary, a moderate amount of testosterone or estrogen is needed to maintain bone health.
Calcium is a major component of bones, and in addition to maintaining sex hormone levels, supplementing with calcium and vitamin D also contributes to bone health. At the same time, we should participate in exercise appropriately and maintain a healthy lifestyle.

How many calories do I need while building muscle ?


In addition to exercising, it is important to eat well. So, how many calories do I need per day in the process?
The effect of calories on muscle building
Calories play an important role in building muscle, and you must consume enough calories to support muscle growth and repair.
The process of building muscle is actually a process of converting the calories you eat into muscle through exercise. If the calories you consume are not enough to maintain your metabolism, there is no spare energy to support muscle build. To build muscle, you need to eat more calories than your body expends.
Adequate calorie intake ensures that users have enough energy for high-intensity workouts, which are essential for stimulating muscle growth. At the same time, if the intake of calories is not enough, it will also cause the body to begin to break down muscle for energy, which is contrary to our original intention to build muscle.
How many calories do I need to eat
For most men and women, a typical daily diet requires more than 2,000 calories. While 2,000 calories is enough for some people with small total weight or low resting metabolism to gain muscle, for most people, it is not enough to support the energy needed for muscle growth. For the cutting phase, this may be sufficient, but for the bulking phase, it is not. For most people, 2,000 calories is roughly a maintenance diet.
2500 calories is enough to provide a surplus in the pupil canal for many people and is suitable for most women and many men to build muscle. However, it is also necessary to eat enough protein to promote muscle growth.
3000 calories is basically enough to provide muscle building calories, but it still varies from person to person. For people who already have a lot of muscle mass or have a faster metabolism, 3,000 calories may not be enough.
So, in general, 2,000 calories is the starting point for bodybuilder's energy. For people who build muscle, in addition to paying attention to calories, they should also pay attention to balanced nutrition, balancing the intake of protein, carbohydrates, minerals, etc.

Overview of Anabolic steroids


Anabolic activity
anabolic steroid activity is a key data that determines the muscle-building capacity of anabolic steroid. We usually default that the anabolic activity of testosterone is 100%. So, which of the other steroids has the highest anabolic activity compared to testosterone (the top five are listed below for reference only)?
Trenbolone's anabolic activity is 500%
Methasteron (superdrol) has 400%-500% anabolic activity
Oxandrolone (anavar) has anabolic activity of 322%-633%
Nandrolone (Deca durabolin, Npp) has anabolic activity of 329% to 492%
Stanozolol (winstrol) has anabolic activity of 320%
Androgen activity
In terms of anabolic activity, Trenbolone is the first choice. In fact, which one to choose depends on its androgen activity. Androgen activity is usually the lower the better, and Trenboline's androgen activity is also very high and not suitable for all bodybuilders. Again, with 100% androgen activity of testosterone, let's look at the top five anabolic steroid with the lowest androgen activity (data for reference only).
Oxandrolone (anavar) has 24% androgen activity (in fact, the data suggest that it has only 5% of the masculine side effects of testosterone).
Methasteron (superdrol) has androgen activity of 20%
Drostanolone (Masteron) has androgen activity of 25%
Stanozolol (winstrol) has androgen activity of 20%-30%
Nandrolone (Deca durabolin, Npp) has 31%-41% androgen activity
Testosterone derivatives or DHT derivatives
In addition to androgen activity, estrogen activity is also a key attribute in evaluating an anabolic steroid. steroid was divided into testosterone derivatives and DHT derivatives. Testosterone derivatives were easier to aromatization and produced estrogen side effects, while DHT derivatives had no water retention and gyno such estrogen side effects.
Testosterone derivatives are: Trenbolone, Nandrolone, Boldenone, dianabol.
DHT derivatives are: Drostanolone, Metenolone, anavar, winstrol, anadrol, proviron, superdrol.
Oral or Injection
In addition to the above attributes of anabolic steroid, the way they are used is also a reason for choice.
Commonly used oral anabolic steroid are: anavar, dianabol, winstrol, anadrol, proviron, superdrol.
Commonly used injectable anabolic steroid are: Testoterone, Trenbolone, Nandrolone, Boldenone, Drostanolone, Metenolone.

How do you get muscle without going to the gym


The most direct way to gain muscle is to train hard, followed by diet and sleep. How to get better training? The first thing that comes to mind is going to the gym, which has all the equipment and professional trainers to show you how to train to gain muscle. However, this all costs money. Is there any way to gain muscle without going to the gym?
Weight exercise
Gaining muscle requires some weight training, and the gym has a lot of auxiliary equipment for weight training, such as bench press, dumbbell squat, dumbbell bench press, dumbbell push machine, pull down machine, etc. If there is no relevant training equipment, buy your own frustration a home dumbbell can also do many aspects of muscle exercise.
In addition to equipment, you can also target different muscle groups with your own weight. Things like push-ups, pull-ups, squats, lunges, planks, and burpees can all help you build muscle and strength without equipment.
gymnastics
Gymnastics is a form of exercise that uses body weight movements and combines them into a routine to build strength and muscles. They often include handstands, muscle ups, squats, and various dynamic movements.
Antistop band
Resistance training with resistance bands. Resistance bands provide resistance across the entire range of motion and can be used to perform exercises such as bicep curls, chest presses, strokes and side raises to work the muscles in the appropriate area.
Outdoor sports
Outdoor activities such as hiking, rock climbing, swimming, soccer, basketball and other sports can help develop muscle mass, strength, and endurance.
Cooperative training
Your training "equipment" can also be your partner. High pull-downs, squats and other exercises can be performed with a partner.
Supplements
Supplements helps gain muscle, and many people choose it to burn fat and increase muscle mass. However, you should keep exercising even if there are supplements.

Where does the natural triiodothyronine T3 come from?


T3 increases the body's metabolic level, contributing to fat breakdown and muscle growth. Where does the body's natural T3 come from?
There are two sources of T3 in the body, one is directly secreted by the thyroid gland, which accounts for 20% of the total T3 in the body. The other is converted from T4, which makes up 80% of the body's total T3.
The thyroid gland directly secretes T3
The production and release of thyroid hormones, T4 and T3 are controlled by a feedback loop on the hypothalamic-pituitary-thyroid axis. T4 and T3 are the main thyroid hormones.
When the body detects low levels of thyroid hormones (T4 and T3), the pituitary gland releases thyrotropin to stimulate the thyroid gland to produce more thyroid hormone. The amount of thyroid-stimulating releasing hormone produced by living organisms depends on the body's need for thyroid hormone. Once the levels of thyroid hormones (T4 and T3) in the blood reach normal levels, the pituitary gland stops releasing thyroid-stimulating releasing hormone. In this way, the system enables the body to maintain constant levels of thyroid hormones (T4 and T3).
In this process, the thyroid hormones T3 and T4 are present at the same time, so under what circumstances is T3 produced, and under what circumstances is T4 produced?
The process of thyroid hormone synthesis can be summarized as four steps: "polyiodide - activation - iodide - condensation". T3 and T4 are formed in the condensation of the last step. In the process of iodination, the ammonia on the phenyl ring of tyrosine is replaced by activated iodine catalyzed by TPO(thyroid peroxidase) to form MIT(monoiodotyrosine) or DIT(diiodotyrosine). Then, in the process of condensation, catalyzed by TPO, one MIT and one DIT condense to produce T3 and a very small amount of rT3, and two Dits condense to produce T4.
This part of T3 is directly generated and accounts for about 20% of the total T3. The other 80% of T3 that the body needs is converted from T4.
How does T4 turn into T3?
T4 is produced by a deiodination reaction, in which an iodine atom is removed by metabolic enzymes in the peripheral tissues to form T3. There are three types of deiodinases involved in this process, type I, type II and type III deiodinases. Type I is found mainly in the liver, kidneys, thyroid, and pituitary gland, type II in the central nervous system, pituitary gland, brown adipose tissue, and cardiovascular tissues, and type III in the placenta, CNS, and hemangiomas. Type III deiodinase mainly converts T4 to rT3, which, unlike T3, is inactive and counteracts some of the effects of T3.
The conversion efficiency of T4 to T3 is different, and the conversion efficiency of young people is higher than that of old people.

What are Dirty bulking and Clean bulking?


Dirty bulking and Clean bulking are terms commonly used to describe two different dietary situations during the bulking cycle.
What is Dirty bulking?
Dirty bulking usually focuses on providing more calories and growing muscle mass. In this process, you don't pay much attention to whether the food calories consumed are far more than the calories needed, or whether these foods are healthy foods.
Choosing Dirty bulking will largely result in eating some junk food, which may include fast food, sugary snacks, fried foods, or other foods that are high in calories but not high in nutritional value. In the process, they also do not pay particular attention to whether they will eat too many calories, just want to speed up the growth of muscles and gain strength through more food intake. In the process, a large amount of fat may be accumulated in the body because the excess calories are not used effectively by the body.
What is Clean bulking?
In contrast to Dirty bulking, clean bulking requires a controlled caloric intake during muscle building, so that the user consumes enough energy for daily exercise without excessive surplus, and avoids excessive fat accumulation after bulking ends. At the same time, clean bulking focuses more on high-quality sources of heat. During this period, lean protein, complex carbohydrates and healthy fats are usually chosen, as well as mineral and trace element intake. This includes including lean meat, fish, eggs, legumes, fruits, vegetables, nuts and other foods in your diet to support your body's health and muscle growth.
Dirty bulking vs Clean bulking
clean bulking looks better, literally. It looks more professional and healthy. Is that the case?
Because clean bulking is actually still on a diet to some extent, user's weight gain in this mode is still under control. As a result, the dirty bulking will gain weight faster than the clean bulking, and the user will gain weight quickly and provide a greater level of strength in this situation. This is a faster way for people who are looking for weight and not so much for lean muscle. However, the side effect of this weight gain is also obvious - fat accumulation. Therefore, if your goal is to lean muscle, the corresponding cutting cycle is essential. Those who chose clean bulking did not gain weight as quickly as dirty bulking, but they gained less fat and their muscles looked thinner and more streamlined.

How to increase strength without adding muscle


Boosting strength without growing muscles at all is very limited, and you usually won't get very far. Because muscles are, to some extent, the carriers of strength. Regular muscle building exercises can help bodybuilders generate more strength in the long term. Bigger muscles can release more potential, but also help improve metabolism, prevent injury and so on.
Improving strength without changing the existing muscle mass is mainly achieved by improving the efficiency of muscle exercise.
In weightlifting, smaller people can lift huge weights. This explosive power (generating a lot of power quickly and efficiently) comes mainly from regular training. Regular high-intensity training can improve neuromuscular efficiency and improve the control of the nervous system over the muscles.
In addition to high-intensity training, you can also improve your strength level with some strength improvements. These include balance, stability, control, coordination and elimination of weaknesses in complex exercises (such as strengthening gluteus muscles to improve squats), speed training. Each of these exercises can lift greater weights without adding extra muscle.
You can build muscle strength without gaining weight, but there is absolutely no need to avoid gaining muscle mass unless you are a professional weightlifter who needs to control their weight. Because muscle gain is a good result of exercise, exercises that target muscle efficiency increase the user's strength level, as you can lift more weight, and as you can last longer in the gym, you also gain muscle gain.
Of course, whether it is to grow muscle or increase strength, you need to cooperate with the corresponding diet to ensure the intake of protein. Diet is an important lesson for users, just as important as exercise.
The growth of muscle, in addition to contributing to the growth of strength, has many benefits. Such as:
Protect your joints from injury.
Helps regulate metabolism and reduces fat storage.
The growth of muscle helps to give the user a more attractive appearance.
The process of building muscle during exercise is a healthy lifestyle.

Is muscle size proportional to strength?


For bodybuilders, muscle size is often more important than strength. From a visual standpoint alone, bigger muscles have more power. So, is it true that muscle size is proportional to strength?
Can increase strength without increasing muscle size
In real life, we can see that the same person without muscles, one person's strength will be significantly greater than another person. This shows that strength does not necessarily reflect the size of the muscle. However, when you continue to exercise and continue to build your strength, you will find that your muscles are bound to grow. Because your exercises are helping you build strength, these exercises are actually helping you build your muscles and burn off your fat.
You can only see strength gain in the short term, but not muscle gain. However, in long-term exercise, with the emergence of muscles and muscle training, strength gain will reach a new level.
Strength is related to the size of muscles
This is one of the reasons why people who build their muscles better have higher strength levels. Strength is actually a skill that uses muscles. It comes from changes in muscles, the nervous system that controls muscles, and the techniques used to train them.
So, strength is related to training, it is related to the mass of the muscles, and it is also related to the control of the muscles by the user. People who use the same muscle mass will show different levels of strength.
Bodybuilders vs. weightlifters
In a comparison of bodybuilders and weightlifters, it was found that bodybuilders mainly trained muscle size and proportion, symmetry, etc. Weightlifters focus on strength training and are relatively small in size and muscle size compared to bodybuilders.
So, bigger muscles provide relatively more power, however, it's not that bigger muscles make more power. If you want to improve your strength in a targeted way, you need to work with the corresponding strength exercises, such as squats, bench presses and hard pulls to lift as much weight as possible. Targeted improvements in muscle efficiency will also allow users to achieve a higher level of strength with the same muscle mass.

What are the most common AAS used by male and female bodybuilders?


Since people discovered the effects of testosterone and extracted it for their own use, a number of derivatives based on testosterone have been developed. These derivatives of testosterone are classified as anabolic steroids (AAS). They all have similar effects to testosterone, and in some ways are better than testosterone.
Testosterone and AAS have been used by Bodybuilders for a long time, so what are the most commonly used AAS among the many, and which is the most popular one for Bodybuilders?

The most commonly used AAS by Bodybuilders
Using a survey of 626 bodybuilders, we put together a table shown below. As can be seen from the table, the most commonly used AAS by Bodybuilder are: Stanozolol, Testoterone, Anavar, Dianabol, Anadrol, Deca-Durabolin, Sustanon, Equipose, Trenbolone, Primobolan, Durabolin. Among them, the AAS most used by male bodybuilders is Stanozolol (winstrol) and Anavar (Oxandrolone) is the most used by female bodybuilders.

The above data is basically consistent with our common cognition.

Stanozolol (winstrol)
Stanozolol is a derivative of DHT that can be used in bodybuilding to greatly increase strength and achieve a dry, hard muscular appearance. An important stat for whether an AAS is worth choosing for bodybuilders is its anabolic activity. The anabolic activity of Stanozolol is 320% of that of testosterone, and the ratio of its anabolic activity to its androgen activity is 30:1. 30:1 is a very good number in AAS. This is probably one of the main reasons why Stanozolol is the most popular AAS.
Anavar (Oxandrolone)
Anavar is the most popular AAS among female bodybuilders because it is the least androgenic of the existing AAS. Studies have shown that the side effects of masculinization are 5% of testosterone. This minimizes the risk of male side effects in women, so Anavar is the first choice for women to use AAS in bodybuilder.
Testoterone
Testoterone is the foundation of all AAS. Testoterone is used by many male bodybuilders as a stack when using other AAS. Here we can see that a larger percentage of female bodybuilders are already using it. Testoterone is the one that is easiest to see when a person is beginning to try using AAS. For female bodybuilders, there is a lot to be gained from developing a good cycle and dosage, and taking care to control side effects.

How to Improve Your Endurance Level in Training


Whether you want to build a stronger body or add more muscle, you need to train hard. However, the basis for you to train hard is that you have enough endurance to do it consistently.
Compared to someone who doesn't exercise at all and someone who keeps exercising, their endurance level is completely different. So, endurance comes from your persistent exercise.
Aerobic Exercise
Aerobic exercise, such as running and cycling, builds heart and lung function and improves endurance. 30 to 60 minutes of aerobic exercise three to five times a week will help increase endurance levels.
Resistance Training
Training with resistance devices can increase muscle endurance and strength and improve fitness. Whole-body training targeting all major muscle groups two to three times a week will increase your basal metabolic rate and burn more calories.
Strength Training
Strength exercises such as dumbbells, push-ups, and squats can increase muscle strength and endurance. Two to three times a week, each time choose 8-12 movements, 3 sets of 8-12 times each. Strength training increases muscle mass, improves neuromuscular coordination, and increases muscle contractions, thereby increasing overall endurance levels.
Irregular Training
Such as step training, running up and down some irregular aerobic exercise, can improve heart and lung function and muscle strength, increase endurance. 1-2 times a week.
Bodybuilder should develop a gradual training plan based on individual fitness and goals, coordinating aerobic, resistance and other exercises, gradually increasing the time and intensity, and periodically modifying and adjusting to maximize endurance.
In addition to training, you should also get enough sleep and eat right to keep your body energized and avoid fatigue and physical decline caused by lack of sleep.

You may lost the weight you have gained if there is no PCT


PCT is post-cycle treatments that are familiar to experienced users, but may be the first time someone new to bodybuilding has heard of them. It is important to understand the role of PCT.
Restart the production of endogenous testosterone
Use of exogenous AAS inhibits the body's natural testosterone production. PCTS use Tamoxifen,clomid and HCG to stimulate the natural production of testosterone, and without PCTS, testosterone levels in the body may remain low for several months, which can lead to muscle loss and the onset of low testosterone symptoms.
Prevent loss of muscle mass
The benefits gained during the AAS cycle rapidly decline due to the decline in testosterone levels. PCTS help bodybuilder recover endogenous testosterone levels quickly, and users can minimize losses with diet and training.
Prevent post-cycle crashes
At the end of the AAS cycle, endogenous testosterone levels are low, and exogenous androgens are no longer supplemented, and the body suddenly faces extremely low androgen levels, which have a great impact on emotional and physical health. Timely PCTS can help prevent negative emotions.
It helps with cardiovascular recovery
Using AAS can put stress on the liver and negatively affect cholesterol levels and blood pressure. PCT give the body time to restore liver health and allow hormone levels, blood fats and blood pressure to return to normal.

What is ester, why add it to steroids?


There are several types of Boldenone available, including Boldenone acetate, Boldenone cypionate and Boldenone undecylenate. When we get to know the relevant information, we will find that they are Boldenones with different half-lives, and the use effect is basically the same. Similarly, common anabolic steroids such as Testosterone, Trenbolone, Nandrolone, Metenolone all have different ester forms. So, what do these esters do, and why are they added to steroids?
Steroid esters themselves are naturally present in the body. Scientists first discovered that many cytochrome steroid producing enzymes use steroid sulfates as substrates, and dehydroepiandrosterone sulfate is one of them. Later, biological synthesis studies showed that maternal steroids could be converted into precursor drugs through esterification of fatty acids on steroids, which could not only prolong the duration of steroid action, but also improve the metabolic stability, water solubility or lipophilicity and oral bioavailability of steroids.
Take testosterone, the body's basic hormone and the most commonly used anabolic steroid by bodybuilders. However, testosterone has a very short half-life, about 5-7 hours for oral testosterone and no more than 1 day for injection. Testosterone's half-life is increased by up to 15 days (Testosterone Undecanoate) when the corresponding ester is added to testosterone, so frequent injections are no longer necessary when uses testosterone ester.
At the same time, oral bioavailability of testosterone is very low due to extensive first-pass metabolism and is not suitable for oral use. Attaching a corresponding ester to testosterone also alters its bioavailability. Testosterone Undecanoate is an oral testosterone ester with excellent bioavailability.
The ester added to the steroid, increases the water solubility or lipophilicity of the steroid, making it easier for Bodybuilders to obtain injectable steroids for better results.

What should be Pay Attention to When You are Going to Change Your Physical with Bodybuilding


We had talked many things about build muscle or get a physical shape with bodybuilding supplements, and explained which bodybuilding supplements, no matter sarms or anabolic steroids would effects muscle grow in its ways. But we should not forget that bodybuilding supplements is not the only way, and it also couldn't be the only way to build muscle or get a better physical shape. Supplements is not the only way, and it also couldn't be the only way to build muscle or get a better physical shape.
Bodybuilding is a sport that changes and builds muscle through planned exercise and diet. The main purpose of Bodybuilding is to achieve the desired muscle size, symmetry, and muscle redefinition.
Key features of the Bodybuilding include:
1. Strength Training for different muscle groups. Commonly used dumbbell training, barbell training, machine training and so on. Focus on the chest, back, shoulder, biceps, triceps and other large muscle groups.
2. Eat a high-protein, high-calorie diet. A lot of protein is needed to repair and rebuild muscle in bodybuilding, as well as enough calories to get the energy and nutrients needed for bodybuilding.
3. Get cardio. Some light aerobic exercise helps to burn fat and increase metabolism, providing a better nutrient absorption environment for muscles.
4. Get enough rest and sleep. Muscle growth requires adequate rest and sleep after intense training to recover.
5. Take sensible supplements. Some commonly used supplements are protein powders. Some bodybuilders also choose sarms (such as mk677, gw501516, mk2866, aicar, etc.) and anabolic steroids (such as test, dianabol, anavar, Boldenone, NPP, etc.). In addition, micronutrients such as calcium, magnesium, vitamin C, and vitamin D are often used in Bodybuilding supplements.
6. Be consistent. To achieve the ideal muscle shape, you need to adhere to a regular training, eating plan and routine over time. This is a slow and constant process of change.

AAS anabolic-androgenic steroid side effects


Side effects of all AAS(anabolic-androgenic steroid) are very similar, and the extent to which a single AAS is affected will vary depending on its androgen activity, whether it is a testosterone derivative or a DHT(dihydrotestosterone) derivative, whether it interacts with 5AR, and whether it interacts with aromatase. But they all have the basic benefits and side effects of AAS.
Cardiovascular
There are cardiac and vascular risks when using AAS to promote muscle development. Androgen induced hypertension may be due to a hypertensive shift in the stress-sodium excretion relationship.
Nervous system
AAS use may produce feelings of high energy and euphoria, but also a tendency to insomnia and irritability. More extreme changes in mental state can lead to extreme swings in mood, from depression to radical elation.
Hiccups are classified as a neurological reaction that can be triggered by a variety of factors. There have been a few published reports of persistent hiccups associated with oral and intravenous glucocorticoid administration, as well as one type of progesterone induced hiccup that is thought to be secondary to glucocorticoid-like effects of progesterone on the brain stem.
Psychology
In addition to the physical effects of exogenous AAS, they can have behavioral effects, including promoting sexual behavior (which may or may not be seen as a bad effect) and possibly increased aggression. Men who use AAS to improve athletic performance appear to be more prone to periodic depression, but young men who have stopped using AAS can also experience depression and fatigue from withdrawal.
Endocrine
Although AAS both have androgenic effects and lead to masculinity, they inhibit endogenous secretion of FSH and LH.
Metabolism
Androgens alone have an adverse effect on blood lipids and can lead to atherosclerosis. However, simultaneous administration of estrogen appears to have a protective effect on lipid profiles.
Liver
In particular, since most oral androgen treatments are performed with 17-substituted compounds (methyltestosterone), there is considerable hepatotoxicity.
Skin
Acne is common in patients who take androgens. When the effects of testosterone and anabolic steroids on sebaceous gland size were studied in a range of male athletes, high doses of all tested products were found to enlarge the glands.
Hair
Hirsutism is common in patients taking androgens and is usually irreversible. In contrast, in women, scalp hair loss may occur.
Musculoskeletal
The ability of androgens to fight osteoporosis is the basis for their use as an estrogen supplement in a type of hormone replacement therapy. Testosterone can increase markers of bone formation. However, if a child is exposed to these substances, the epiphysis can close prematurely and growth can stop.
Sexual function
In men, the (usually needed) effects may include increased libido. Over time, androgen therapy in men can lead to reduced testicular volume and anspermia or oligospermia due to gonadotropin suppression.

How does AAS grow muscle?


We all know that using AAS helps build muscle, but how does AAS build muscle? When referring to AAS, we commonly use the term testosterone and testosterone derivatives. Testosterone is the basis of all AAS and is also a kind of AAS. Understanding how testosterone builds muscle will help you understand how AAS builds muscle.
How does testosterone stimulate muscle growth?
The most common understanding of how testosterone stimulates muscle growth is that it activates and increases the number of muscle fiber precursor cells. Muscle fiber progenitor cells are also called satellite cells. Once activated, these precursors may blend into existing muscle fibers, making them larger, or satellite cells may fuse together to form new muscle fibers.
In addition to activating and increasing satellite cells, testosterone also increases the number of muscle nuclei and thus the number of available androgen receptors to which testosterone can bind in muscle. When combined with training, which increases the sensitivity of androgen receptors and depletes amino acids necessary to support protein synthesis, testosterone has an increased impact on muscle and performance.
Testosterone is also anti-catabolic because it blocks the ability of catabolic hormones, such as cortisol, to bind to their main receptors.
Therefore, testosterone is both an anabolic and anticatabolic steroid that builds and maintains muscle mass and helps with rapid recovery after exercise.
Testosterone has also been shown to increase the energy of muscle contractions by increasing the amount of calcium released within cells, thus providing strength gains and explosive power during training.
Testosterone also stimulates red blood cell development. More red blood cells in the blood give the muscles better oxygen-carrying capacity, which improves endurance during training and helps bodybuilder train for longer.
In addition to gaining muscle mass, Bodybuilder also helps boost endogenous testosterone levels.
Testosterone is the most basic AAS. Synthetic AAS are derived from testosterone and have similar anabolic and anticatabolic effects as testosterone, and they stimulate muscle growth in the same way.

How to eat in bodybuilding


How to eat in bodybuilding is the most important thing for bodybuilders. Eating the right, is the basic of bodybuilding.
Bodybuilder exercises to gain a large amount of muscle that can't be gained with exercise alone. A lot of muscle needs a lot of protein, and the process of exercise also needs a lot of energy. bodybuilder gets energy and protein by eating regularly, and professional Bodybuilders need to eat six meals a day.
Bodybuilder usually includes protein with every meal, some in the form of a shake. A full meal usually includes lean animal protein, such as grilled chicken breast or fish fillets, vegetables and perhaps starches such as sweet potato or rice dumplings. Dietary fat intake is usually strictly controlled, and this is achieved by steaming, roasting or boiling most foods.
A proper diet will help bodybuilder build a better muscle, but there are still some issues to be aware of.
Calorie control
Most bodybuilding lovers also don't spend hours in the gym training a body part. They have a limited amount of time to exercise and therefore don't use as much energy as a professional bodybuilder. Six meals a day can add up quickly, and if you don't distribute each meal perfectly, excess food can easily be turned into fat if it isn't used up.
Controlled meal frequency
Some people say that eating frequently (like every 2 hours or so) will speed up your metabolism, but there is actually no scientific evidence for this. Experienced Bodybuilder once recommended waiting at least 2 hours after consuming liquid protein or 4 hours after consuming solid food.
carbohydrate
If you want to slim down, you need to limit your carbohydrate intake. However, the heavier the bodybuilder, the higher the need to eat carbohydrates. If you do need carbohydrates, you should eat the starchest carbs after a workout or in the morning. If you still can't slim down, you need to cut starchy carbs from your breakfast.
While for most people the main interest is to be reasonably slim all year round, for bodybuilder it is different. Bodybuilder eats more calories in the off-season to gain muscle, then changes its diet to lose the fat gained during weight gain. So the bodybuilder diet changes as it cycles between weight gain and fat loss.

The classification of Steroid


For bodybuilders, whenever steroids are mentioned, the reference must be to anabolic steroids. So, we use steroid anabolic steroid. However, normally speaking, steroid is not equal to anabolic steroid, anabolic steroid is just one type of steroid. So, how do we classify it?
1. From the view of steroid, it can be divided into five categories, which are glucocorticoid, corticosteroid, progesterone, estrogen and androgen.
Glucocorticoids are involved in the production of glucose and glycogen, the breakdown of proteins and fats, and the prevention of inflammation. Glucocorticoids are involved in stress response and are mainly produced by the adrenal cortex. An important glucocorticoid is cortisol.
Corticosteroids work with the kidneys to regulate blood volume and blood pressure. They are also produced primarily by the adrenal cortex. Glucocorticoids and corticosteroids are sometimes called corticosteroids because they are both produced by the adrenal cortex. An important salt corticosterone is aldosterone.
Progesterone is involved in the menstrual cycle and pregnancy maintenance. They are synthesized mainly by the corpus luteum. The main progesterone is progesterone.
Estrogen promotes the development of a woman's secondary sex characteristics and plays a role in the ovarian cycle. They are made primarily by the ovaries. An important type of estrogen is estrone.
Androgens promote the development of male secondary sex characteristics. They are produced mainly by the testicles. One important androgen is testosterone.
From the above, we can see that anabolic steroids come from testosterone, which is a major male hormone, while androgen is a kind of steroid. So, anabolic steroid is a kind of steroid, we can't take it strictly speaking, it's called anabolic steroid.
2. In terms of the function it achieves, it can be divided into three categories, which are sex hormones, corticosteroids and anabolic steroids.
Among them:
Sex hormones, including estrogen, progesterone and androgens
Corticosteroids, including corticosteroids and glucocorticoids
Anabolic steroid, which is a synthetic androgen.
We can see from the above, it can be classified into two classes based on the function of steroid, namely, sex hormones and corticosteroids. Because anabolic steroid is actually an androgen. It's just that sex hormones and corticosteroids are produced by the body itself, while anabolic steroids are usually synthetic.

How effective is steroids testosterone in muscle?


It can be frustrating to exercise and diet as hard as you can, only to find that your muscles stop moving after a certain point. Steroid use can help you break that limit quickly and continue to build muscle.
That's why large numbers of men and women of all ages use steroids each year to get bigger, thinner and stronger faster.
A study of the steroid testosterone demonstrated a dramatic difference in outcomes between steroid use and exercise alone.
In a study conducted by scientists at Charles R. Drew University of Medicine and Science, 43 men were randomly assigned to one of four groups.
The first group took a placebo and did not exercise.
The second group took testosterone but did not exercise.
A third group took a placebo and exercised.
A fourth group took testosterone and exercised.
All groups followed a standardized diet, and the exercisers performed squats and bench presses three times a week, for a total of 12 sets of six reps, with varying weights lifted during each workout. Muscle size was measured by MRI and strength was determined by the maximum value of an actual repeat.
The results show that the steroid testosterone has incredible effects on muscle growth.
The first placebo group did not gain muscle.
The second group that got only testosterone gained an average of 6.6 pounds of muscle.
The third exercise-only group gained an average of 4.4 pounds of muscle.
The fourth testosterone and exercise group gained an average of 13 pounds of muscle.
Compared to those who lifted weights three times a week, the testosterone-only group gained more muscle mass, while the testosterone-and-exercise group gained three times as much muscle mass on average.
The thing to keep in mind is that men use 600mg of testosterone per week. By today's standards, that's a beginner's dose.
Muscle and strength aren't the only benefits of using steroids ---- They can also help you stay slim.

Why AAS using could damage liver?


Liver injury is an inevitable problem during the use of AAS. Many AAS have certain effects on the liver. Then, how does AAS damage the liver?
The most common tissue injuries of the liver are vascular congestion, degeneration, inflammation of the liver tissue, increased cytoplasmic fat vacuoles, resulting in liver deformity and sclerosis, thereby destroying the liver tissue and replacing it with connective tissue. The resulting fiber chains connect the liver region and create bridging fibrosis. With fibrosis and parenchymal injury, the normal structure of the liver will be destroyed and eventually cirrhosis will develop.
Since the liver is a major site of steroid metabolism, it may be susceptible to AAS. However, it is not clear how AAS damage the liver. Studies have shown that AAS can affect liver health in the following ways.
1. ALT (alanine aminotransferase) and AST (aspartate aminotransferase) levels were above the normal range in individuals using AAS, and were close to the normal range after 12 weeks of disuse of these substances. That is, elevated ALT and AST levels affect liver health, but this effect is reversible.
2. Use of AAS interferes with the normal cycle of testosterone production in the body (i.e. inhibits endogenous testosterone production). By inhibiting testosterone production, blood cholesterol is no longer converted to pregnenolone, which raises blood cholesterol. It's one of the factors that causes fatty liver disease. So some AAS use increases the risk of fatty liver disease.
3. The presence of ethyl or methyl groups in the drug structure of some AAS is usually the C17 position of the chemical structure of the added compound, which makes the AAS toxic to the liver and thus affects the liver health, and may be one of the important reasons for the elevated liver enzyme level in the blood. Therefore, bodybuilder can choose an AAS based on its chemical structure to determine whether the compound is bad for the liver, thus avoiding this AAS Or use drugs to protect your liver.
Although the adverse effects of AAS on liver enzymes are significantly reduced over time, the dose and cycle length of AAS use appear to be important factors in the initiation of liver injury. Thus, bodybuilder can arrange the AAS cycle and dosage appropriately after learning about the liver damage that AAS can cause.
www.astersteroids.com

Effects of AAS on the liver


The effect of AAS on the liver is an issue that bodybuilder must consider when using AAS. Although the adverse effects of AAS on certain liver enzymes are significantly reduced over time after discontinuation of the drug. However, long-term, high dose use of AAS will inevitably affect liver health.
Long-term, high-dose use of AAS can lead to the accumulation of these drugs, or their metabolic production, in the liver, which increases the likelihood of liver diseases such as tumors and hepatitis.
AAS are a class of compounds derived from testosterone that have been widely used since the late 1930s to treat hypogonadism and severe burnout. Physiologically, AAS can increase skeletal muscle mass and protein synthesis, and improve muscle size, weight, and strength. These steroids affect cells by interacting with the central nucleus and causing biochemical changes, and because of their solubility in fat, disperse in the cell, bind to proteins, enter the nucleus and activate protein synthesis. Many Bodybuilders use AAS to improve performance.
High levels of AAS use are associated with adverse cardiovascular, renal, hormonal, reproductive, and psychiatric effects, with liver damage being the most common.
The liver is the largest gland in the body, and complications such as intrahepatic cholestasis, hepatitis, and hepatocellular carcinoma are often associated with changes in liver function as well as increases in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and in some cases bilirubin. Long-term large use of AAS can lead to cholestasis and elevated liver enzymes, which can damage liver health.
The liver itself has a certain detoxification function. The liver detoxifies many different drugs through chemical changes or excretes them into the bile. As a result, steroid hormones that are not present in tissues are usually converted by the liver to androsterone and dihydroepiandrosterone, which are immediately bound or acidified, and then excreted into the intestine via bile or into the urine via the kidneys.

A study of aggression and psychological distress caused by AAS in bodybuilder


AAS causes aggression and psychological distress
AAS(anabolic androgenic steroids) are both derivatives of testosterone and testosterone, so AAS are androgens. Androgen stands for male sex hormone, and when you describe someone who is full of male sex hormone, you can imagine aggression as well as muscle and strength.
Research on aggression and psychological distress associated with the use of AAS in bodybuilder could help identify individuals and groups most sensitive to the negative and psychological consequences of AAS use to facilitate the development of targeted interventions.
For AAS users, most of the data is on men, and there is a significant lack of data on female bodybuilder studies.
Participants included 206 Bodybuilders using AAS (58.3% female) with a history of regular AAS use for at least 6 months prior to participating in the data collection. Participants ranged in age from 14 to 56 years (M=26.89,SD=7.12 years).

In the study, Cronbach for physical aggression, verbal aggression, hostility, and anger were 0.73, 0.70, 0.77, and 0.69, respectively. Cronbach coefficient of psychological distress was 0.82.
Female and male AAS users in the study averaged 4.37 hours and 6.19 hours of weight training per week at the gym. The mean duration of AAS use was 1.51 years for men and 1.19 years for women.
The experimental results show that:
The proportion of highly aggressive and moderate psychological distress users was 7.63%; The male accounted for 91.67% and the female accounted for 8.33%.
The proportion of moderate aggression and moderate psychological distress was 18.645; Males accounted for 80.42% and females accounted for 19.58%.
The proportion of moderate aggression and mild psychological distress was 11.71%; Males accounted for 32.46% and females accounted for 67.54%.
The proportion of mild aggression and moderate psychological distress was 11.62%; Males account for 30 percent and females for 70 percent.
Low aggression and mild psychological distress accounted for 39.06% of the users; The male accounted for 10.51% and the female accounted for 89.49%.
These data may be influenced by AAS use methods (e.g., bulking, cycling, and stacking) and individual constitution. However, the experimental results still showed that a large number of exogenous AAS increased the occurrence of aggression and psychological distress in bodybuilder. When using AAS, bodybuilder should follow the doctor's advice, control the dosage and cycle length, etc., so as to use AAS more safely.

How to prepare and inject your hcg dosage


In the bodybuilding space, hCG is increasingly used in combination with various AAS cycles.
When exogenous AAS enters a man's body, the natural negative feedback loop causes the body to shut down its own testosterone production by turning off the hypothalamic-pituitary-gonadal axis (HPGA). This can lead to testicular atrophy, etc. hCG is commonly used to maintain and restore testicular size and normal testosterone production during and after a steroid cycle.
High levels of AAS that mimic the body's natural testosterone trigger the hypothalamus to shut down its production of gonadotropin-releasing hormone (GnRH) from the hypothalamus. Without GnRH, the pituitary gland stops releasing luteinizing hormone (LH).LH usually travels from the pituitary through the bloodstream to the testes, where it triggers the production and release of testosterone. Without LH, the testes stop producing testosterone.
In male bodybuilder, hCG helps restore and maintain testosterone production in the testes by mimicking LH and triggering testosterone production and release.

How to prepare and inject your hcg dosage is described in detail below
1. Prepare hCG power, 5000IU as an example, bacteriostatic water, sterilized alcohol, 25 gauge syringe (or 27 gauge syringe)
2. Open the cap of the hCG and antibacterial water to reveal the rubber cork, through which the needle of the syringe is inserted into the bottle.
3. Use alcohol to disinfect the rubber stoppers of hCG powder bottles and antibacterial water bottles
4. Open the cap of the syringe needle and disinfect it with alcohol.
5. Insert the sterilized syringe needle from the rubber stopper into the bacteriolytic water bottle, and draw 2ml bacteriolytic water twice.
A helpful trick is to inject as much air into the bacteriab as you want to pump out, in this case preventing a vacuum in the bacteriab and helping to pump out the solvent faster.
6. Pour the extracted 2ml bacterial-inhibiting water into the hcg power bottle.
We now have 2ml of the formulated solution containing 5000IU hCG, so each 0.1ml solution contains 250iu hCG. If our dose is 500IU per day, 0.2ml of the finished solution should be taken each time.
If a smaller needle needs to be replaced, sterilize it.
7. Remove the poisoned syringe and extract 0.2ml of finished hCG solution. Use alcohol to disinfect the needle and the skin at the injection site. Then, the needle is inserted under the skin and the plunger is slowly pushed to complete the injection.
8. After the injection, put the hCG in the refrigerator for storage.

The use of peptides hCG


hCG is administered primarily by intramuscular injection (IM), but also subcutaneously (SC).
The average (3ml 22-25G x ½-1 ½") syringe was sufficient for IM injection, but an insulin syringe (½-1ml 28-30G x ½-1") was recommended for SC injection.
The study found little difference in results between intramuscular and subcutaneous injections. The only difference is the speed of release at the injection site and the time required to reach the plasma peak. Intramuscular injection is 6 hours, subcutaneous injection is 16-20 hours.

If used to treat hypogonadism, short-term treatment is currently recommended for 6 weeks and long-term treatment for 1 year, depending on individual needs.
Short-term medication is usually given at 500-1000 units three times a week for three weeks. Then the dose was the same twice a week for 3 weeks.
Long-term injection of 4000 units, 3 times a week, for 6-9 months. This was then reduced to 2,000 units three times a week for three months.

hCG is sealed in a vial or ampoule as a freeze-dried powder (freeze-dried). The commonly used hCG specifications are 2000IU, 5000IU and 10000IU.
hCG freeze-dried powder should be stored at room temperature between 15 and 30 degrees Celsius. It should be reformulated with appropriate bacteriostatic water (or sterile water) before administration. The prepared hCG solution needs to be refrigerated at a temperature of about 2-8 degrees Celsius.
The prepared hCG solution should be used within 30 days as far as possible.

When preparing hCG solutions, the concentration of hCG per ml of solution depends on the concentration of freeze-dried powder and the volume of thinner. For example, if 5000IUs hCG is diluted with 5ml of solvent, the resulting solution contains 1000IUs hCG per ml. Similarly, if 5000IU hCG is diluted with 10ml of solvent, the resulting solution contains 500IU/ml of hCG.
Bacteriostatic water should be used as a solvent when preparing a 30-day dose at a time.
Because sterile water diluted solution is more likely to breed bacteria than oil solution, always clean the top of the bottle with alcohol thoroughly when injecting hCG solution, and the needle used for injection must also be sterile.
Due to the fragility of protein hormones, if kept at room temperature after preparation, the molecules will denature and be destroyed, and hCG will become ineffective.
Violent shaking of the recombinant hCG will also destroy the protein molecules and should be avoided during preparation.

What are selective androgen receptor modulators?


When someone asks, what is a SARM? We all know that SARM is a selective androgen receptor modulator.
So what are selective androgen receptor modulators?
Before we know what a selective androgen receptor modulator is, we need to understand the question "What is an androgen receptor?" "What is a regulator?" "What is selectivity?"

What are androgen receptors?
The main form of androgen is testosterone. Androgens play an important role in the body. In addition to reproduction, it can also maintain the balance of hormones in the body, stimulate protein anabolism, promote nitrogen deposition and increase the number and thickness of muscle fibers.
Androgens perform their functions by binding to androgen receptors.
The androgen receptor is a 120,000 Dalton molecular weight protein that is synthesized under the guidance of genes on the X chromosome. Androgen receptors are the intermediate substances in the action of androgens. Testosterone can only work by binding to androgen receptors. If there is no androgen receptor in the body, the androgen does not stimulate the tissue response. If androgen receptors are not sensitive, it will be difficult to build muscle.
Sensitivity to androgen receptors varies from person to person. Some people have large muscle size and low body fat, but their testosterone levels are actually not high in blood tests, probably because they have high androgen receptor levels. Some people train hard and eat well, but their muscles grow very slowly. A big reason for this is that the androgen receptors in the body are not sensitive.
Androgen receptor modulator (sarm) is designed to optimize this process and improve the efficiency of muscle synthesis.

What are receptor modulators?
In pharmacology, receptors are biomacromolecules composed of glycoproteins or lipoproteins that are present in the cell membrane, cytoplasm, or nucleus.
Receptor is a broad term in cell biology, referring to any biological macromolecule that can bind to hormones, neurotransmitters, drugs or signaling molecules within cells and cause changes in cell function.
Receptors are the components of cell membrane or cell that can recognize and bind to bioactive molecules, which can accurately amplify and transmit the signals recognized and received to the cell interior, thus causing biological effects.
When the receptor in the body is not sensitive, it will lead to the reduction of the binding rate with its ligand, can not achieve the corresponding effect. Receptor regulation can increase the sensitivity of the receptor and thus increase the probability of binding the receptor to its ligand.
Selective androgen receptor modulator (sarm) makes the androgen receptor more sensitive and can bind to more androgens, thus improving the efficiency of muscle synthesis.

What is selective?
Selective is the key word in selective androgen receptor modulators (sarm).
As bodybuilder increases the amount of androgens in the blood, it also adjusts the androgen receptors to bind to more androgens. At this time, if all the androgen receptors in the body are binding with androgens, the concentration of androgens is the highest in the prostate. A large number of androgens and androgen receptors are bound in the prostate, which will cause problems such as enlargement of the prostate. At the same time, androgen receptors in different parts of the body become sensitive and bind more to androgens, causing side effects such as acne and hair growth.
Selective androgen receptor modulators (SARMS) are selective and selectively bind to androgen receptors in bone and muscle to promote muscle growth and bone health without affecting the prostate and without a large number of androgen side effects.

Exercise training promotes anabolism in the body


Numerous studies have shown that exercise training increases baseline levels of testosterone, IGF-1, SHBG, hGH, and DHEA in both men and women.
The mass and strength of a man's muscles peak around the age of 30, losing 115% per decade from the age of 50 until the age of 70, when they have about 30% of their strength.
About 50 percent of men over the age of 30 see their levels of testosterone, the important anabolic hormone in men, drop by about 1 percent each year. The decline in testosterone levels in men as they age reduces the anabolic effects of skeletal muscle, which negatively affects muscle performance, muscle mass and bone mineral density.
In addition to declining testosterone levels, levels of growth-promoting hormone also decline with age. Both hGH and its main downstream protein insulin-like growth factor 1 (IGF-1) decrease with age. After age 20, HGH production decreases by about 14% every 10 years. hGH and IGF-1 are also significant anabolic compounds that increase cell proliferation, cell differentiation and energy metabolism, and prevent cell apoptosis.
Exercise training is a non-drug strategy that can counteract the physiological changes that occur with age. Studies have shown that the effects of exercise training on some synthetic metabolites in the body are as follows:
Testosterone - Exercise tends to lead to an increase in total testosterone from small to large. Studies have shown that both men and women have an increase in basic total testosterone after exercise training, with an effect size of 0.19-3.37, from a small increase to a large increase.
IGF-1- In all studies, levels of IGF-1 generally increased after exercise training, with significant increases from small to large. IGF-1 plays an important role in muscle development and insulin sensitivity. Studies have shown that after exercise training, the IGF-1 level increase effect size is 0.27-1.03 for both men and women, with a small to medium increase.
hGH- All subjects in the study had an increase in hGH, with effects ranging from small to large. The increased effect size of hGH in response to physical training ranged from 0.29 to 2.58, with small to very large increases.
DHEA and DHEA-S- A small to large increase in DHEA and DHEA-S after training has been observed in studies. Men also have a higher response to DHEA-S than women, and decreased DHEA levels are associated with decreased muscle mass and strength in men. Human studies have reported increased effect sizes of DHEA after training ranging from 0.37 to 1.71, with increases ranging from small to large.

Anabolic and catabolic homeostasis for bodybuilder


The main purpose of bodybuilder is to grow muscle, which requires anabolism, and catabolism causes loss of muscle mass.
Anabolism vs catabolism
Anabolism and catabolism are two completely opposite processes. Anabolic reactions require energy, catabolic reactions produce energy. Anabolism involves taking simple molecules and building them into more complex ones, using energy in the process. Catabolism, in contrast, breaks down complex molecules into simpler ones and produces energy in the process.
Anabolism for bodybuilder
To bodybuilder, the process of growing muscle is anabolism, the synthesis of muscle-forming proteins. In the process of making muscle proteins, energy is needed. The main source of energy at this point is the food ingested by bodybuilder.
But it's not the food you eat that can be converted into muscle protein. Muscle's anabolic process also requires its hormone counterpart to turn it on. The body's natural anabolic hormones include testosterone, growth hormone and estrogen.
When the body's natural anabolic hormones are insufficient, the protein intake does not necessarily produce muscle protein. bodybuilder uses supplements such as AAS, such as testosterone, or hGH, which are high in anabolic activity to help build muscle mass.
Catabolism for bodybuilder
For any human being, the body is no longer catabolic. Because life support requires energy. Normally we get our energy from food, when we don't have enough, we get our energy from burning muscle, and then we get our energy from burning fat.
The catabolism of muscles is unacceptable to bodybuilder. However, when the bodybuilder does not consume enough energy, the body actively burns muscle for energy. At this point, if you keep your food intake adequate, won't the muscle break down? If you eat enough energy and keep moving, you can stop your muscles from breaking down. But at the same time, fat is increasing rapidly. For bodybuilders in the cutting phase, they cannot eat more food in order to reduce fat and face muscle catabolism.
<astersteroids.com/anabolic-and…

"Steroids", "anabolic steroids" and "anabolic-androgenic steroids"


"Steroids", "anabolic steroids" and "anabolic-androgens steroids" are three words commonly used in bodybuilding. Usually they represent testosterone, testosterone derivatives, testosterone variants and other synthetic male hormones. But obviously, these are three different kinds.
Steroids
Steroids are biologically active organic compounds with four rings arranged in a pecific molecular configuration. Its core structure is usually 17 C atoms connected in four rings, and can also be modified more radically, such as cutting one of the rings to produce a new steroid. steroids are also divided into plant steroids and animal steroids, which are divided into sex hormones (including androgens, estrogens and progesterone), corticosteroids (glucocorticoids and salocorticoids) and anabolic-androgenic steroids. For bodybuilders, the usual reference to steroids is anabolic-androgenic steroids.
Anabolic steroids
The term anabolic steroids was invented during the golden age of steroid pharmacology after World War II to define an idealized androgen. We see from its name that it has only 'anabolic' and no 'androgenic'. The initial hope was to develop a steroid that did not have masculine features but maintained myotrophic properties and could be safely used in children and women. However, after a concerted effort by all the industry, it was discovered that such steroids do not actually exist. By changing the structure of the steroid, researchers can make a new steroid with less androgen activity and more metabolic activity, but not a new steroid without androgen at all. However, the term anabolic and androgenic steroids stuck, becoming an ideal expectation for anabolic-androgenic steroids.
Anabolic-androgenic steroids
Anabolic-androgenic steroids are what Bodybuilders call anabolic steroids<astersteroids.com/steroids-ana…
, also known as AAS. It is a steroid androgen that includes both natural androgens like testosterone and structural variants of testosterone, as well as synthetic androgens that have similar effects to testosterone. Synthetic AAS are usually designed to develop greater synthetic metabolism and less androgen, resulting in greater musculogenesis and fewer androgen side effects.

The formation of the HPTA and the role of positive and negative feedback mechanisms


Formation of HPTA
All components of the hypothalamic-pituitary-testicular axis (HPTA) are established during fetal life, and its first activation occurs during the neonatal period, when circulating testosterone (mini puberty) reaches adult male levels for several months and produces androgenic imprinting in non-reproductive tissues. After a surge in the neonatal period, HPTA becomes stationary during the 10 years of childhood. Studies have shown that at least four gene activity mechanisms limit the activity of the hypothalamic-pituitary-testicular axis (HPTA) during these 10 years.
The HPTA axis is not reactivated until puberty.
Hypothalamic gonadotropin-releasing hormone (GnRH) neurons are functional at birth, but after the perinatal androgen surge, they are strongly inhibited directly in infancy and cannot function. Until puberty begins, waking up dormant hypothalamic GnRH neurons and releasing GnRH. GnRH secreted by the hypothalamus drives the pituitary gland to secrete gonadotropin, which ultimately leads to testicular growth and maturation, thus completing spermatogenesis and hormone production to produce circulating testosterone concentrations in adult males. This leads to testicular growth, which is the earliest and most prominent external manifestation of male puberty. After the completion of puberty, HPTA is formalized and comes into play.
Positive feedback of HPTA
After birth, testosterone output of the testicle is mainly regulated by the pulsating mode of pituitary LH secretion. This is driven by the intermittent secretion of GnRH from hypothalamic neurons into the pituitary venous blood flow, providing a direct short-circuiting pathway for pituitary gonadotropin. The pituitary gonadotropin secretes LH at high amplitude pulses at intervals of approximately 60 to 90 minutes. LH stimulates Leydig cytokine production by increasing the availability of substrate (cholesterol) and activating rate-limiting steroid-producing enzymes and cholesterol transporters.
This pattern maintains the sensitivity of testicular interstitial cells to LH, thus maintaining the testosterone secretion pattern in mature males.
Negative feedback of HPTA
Testosterone inhibits pituitary gonadotropin secretion by inhibiting hypothalamic GnRH, which is a key element in testicular negative feedback loop. This negative feedback involves the effect of testosterone through androgen receptors and estradiol in the hypothalamus. This eventually leads to a decrease in the frequency of the GnRH pulse in the hypothalamus and a decrease in the amplitude of the LH pulse due to the decreased secretion of GnRH and the gonadotropin response to GnRH stimulation. In contrast, the small proportion of estradiol in the blood directly secreted by the testes means that circulating estradiol is under minimal physiological regulation and is unlikely to have a significant impact on the negative feedback regulation of male physiological gonadotropin.