Effects of AAS on the liver
The effect of AAS on the liver is an issue that bodybuilder must consider when using AAS. Although the adverse effects of AAS on certain liver enzymes are significantly reduced over time after discontinuation of the drug. However, long-term, high dose use of AAS will inevitably affect liver health.
Long-term, high-dose use of AAS can lead to the accumulation of these drugs, or their metabolic production, in the liver, which increases the likelihood of liver diseases such as tumors and hepatitis.
AAS are a class of compounds derived from testosterone that have been widely used since the late 1930s to treat hypogonadism and severe burnout. Physiologically, AAS can increase skeletal muscle mass and protein synthesis, and improve muscle size, weight, and strength. These steroids affect cells by interacting with the central nucleus and causing biochemical changes, and because of their solubility in fat, disperse in the cell, bind to proteins, enter the nucleus and activate protein synthesis. Many Bodybuilders use AAS to improve performance.
High levels of AAS use are associated with adverse cardiovascular, renal, hormonal, reproductive, and psychiatric effects, with liver damage being the most common.
The liver is the largest gland in the body, and complications such as intrahepatic cholestasis, hepatitis, and hepatocellular carcinoma are often associated with changes in liver function as well as increases in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and in some cases bilirubin. Long-term large use of AAS can lead to cholestasis and elevated liver enzymes, which can damage liver health.
The liver itself has a certain detoxification function. The liver detoxifies many different drugs through chemical changes or excretes them into the bile. As a result, steroid hormones that are not present in tissues are usually converted by the liver to androsterone and dihydroepiandrosterone, which are immediately bound or acidified, and then excreted into the intestine via bile or into the urine via the kidneys.
Long-term, high-dose use of AAS can lead to the accumulation of these drugs, or their metabolic production, in the liver, which increases the likelihood of liver diseases such as tumors and hepatitis.
AAS are a class of compounds derived from testosterone that have been widely used since the late 1930s to treat hypogonadism and severe burnout. Physiologically, AAS can increase skeletal muscle mass and protein synthesis, and improve muscle size, weight, and strength. These steroids affect cells by interacting with the central nucleus and causing biochemical changes, and because of their solubility in fat, disperse in the cell, bind to proteins, enter the nucleus and activate protein synthesis. Many Bodybuilders use AAS to improve performance.
High levels of AAS use are associated with adverse cardiovascular, renal, hormonal, reproductive, and psychiatric effects, with liver damage being the most common.
The liver is the largest gland in the body, and complications such as intrahepatic cholestasis, hepatitis, and hepatocellular carcinoma are often associated with changes in liver function as well as increases in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and in some cases bilirubin. Long-term large use of AAS can lead to cholestasis and elevated liver enzymes, which can damage liver health.
The liver itself has a certain detoxification function. The liver detoxifies many different drugs through chemical changes or excretes them into the bile. As a result, steroid hormones that are not present in tissues are usually converted by the liver to androsterone and dihydroepiandrosterone, which are immediately bound or acidified, and then excreted into the intestine via bile or into the urine via the kidneys.