What is ester, why add it to steroids?
There are several types of Boldenone available, including Boldenone acetate, Boldenone cypionate and Boldenone undecylenate. When we get to know the relevant information, we will find that they are Boldenones with different half-lives, and the use effect is basically the same. Similarly, common anabolic steroids such as Testosterone, Trenbolone, Nandrolone, Metenolone all have different ester forms. So, what do these esters do, and why are they added to steroids?
Steroid esters themselves are naturally present in the body. Scientists first discovered that many cytochrome steroid producing enzymes use steroid sulfates as substrates, and dehydroepiandrosterone sulfate is one of them. Later, biological synthesis studies showed that maternal steroids could be converted into precursor drugs through esterification of fatty acids on steroids, which could not only prolong the duration of steroid action, but also improve the metabolic stability, water solubility or lipophilicity and oral bioavailability of steroids.
Take testosterone, the body's basic hormone and the most commonly used anabolic steroid by bodybuilders. However, testosterone has a very short half-life, about 5-7 hours for oral testosterone and no more than 1 day for injection. Testosterone's half-life is increased by up to 15 days (Testosterone Undecanoate) when the corresponding ester is added to testosterone, so frequent injections are no longer necessary when uses testosterone ester.
At the same time, oral bioavailability of testosterone is very low due to extensive first-pass metabolism and is not suitable for oral use. Attaching a corresponding ester to testosterone also alters its bioavailability. Testosterone Undecanoate is an oral testosterone ester with excellent bioavailability.
The ester added to the steroid, increases the water solubility or lipophilicity of the steroid, making it easier for Bodybuilders to obtain injectable steroids for better results.
Steroid esters themselves are naturally present in the body. Scientists first discovered that many cytochrome steroid producing enzymes use steroid sulfates as substrates, and dehydroepiandrosterone sulfate is one of them. Later, biological synthesis studies showed that maternal steroids could be converted into precursor drugs through esterification of fatty acids on steroids, which could not only prolong the duration of steroid action, but also improve the metabolic stability, water solubility or lipophilicity and oral bioavailability of steroids.
Take testosterone, the body's basic hormone and the most commonly used anabolic steroid by bodybuilders. However, testosterone has a very short half-life, about 5-7 hours for oral testosterone and no more than 1 day for injection. Testosterone's half-life is increased by up to 15 days (Testosterone Undecanoate) when the corresponding ester is added to testosterone, so frequent injections are no longer necessary when uses testosterone ester.
At the same time, oral bioavailability of testosterone is very low due to extensive first-pass metabolism and is not suitable for oral use. Attaching a corresponding ester to testosterone also alters its bioavailability. Testosterone Undecanoate is an oral testosterone ester with excellent bioavailability.
The ester added to the steroid, increases the water solubility or lipophilicity of the steroid, making it easier for Bodybuilders to obtain injectable steroids for better results.