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Losing weight is easy, right?
Losing weight is a very simple thing. Quit drinking, improve diet, exercise more. It doesn't get any more complicated than that. It’s really no more complicated than that unless you have medical issues or disability. Losing weight can be hard if you can't be strict with yourself.
Quit drinking
“Quit drinking alcohol and soda, exercised 30-1hr most days of the week, nothing crazy but just keeping it insistent, and cut portion sizes slightly. Lost 80 lbs last year doing that .Went from 265 down to about 185.”
People don’t realize how many calories are in alcohol. And it’s no just beer, a shot of vodka has 100 calories in it. Light beer is around the same, and if you want a craft beer, 200-300 calories is pretty common.
“I’m a little older than the target of the question (45 to be exact), but I lost about 30 lbs in just a few months when I quit drinking."
Improve diet
Weight loss is based on Calories in < calories out, therefore, diet control is the most basic.
Don't fill your calorie needs with Coca-Cola or junk food. Eat healthy, home-cooked meals and get plenty of protein.
Some people have studied people who eat healthily, but still can't lose weight. Found that they were always eating far more calories than they reported. "I only had a salad today." filled with lumps of cheese and smothered in dressing. "I only ate 500 calories "for dinner" may be true, but there are two 350-calorie snacks and a 500-calorie dessert before the meal.
When you're trying to lose weight, a tablespoon of oil can make the difference between losing weight or not. One tablespoon of oil has as many calories as 4 cups of broccoli. If you say you only eat broccoli but don't lose weight, it's because it gets thrown into the oil before cooking.
Exercise more
Controlling your diet will make you healthier, burn off the calories you consume each day, and prevent excess calories from turning into fat. The more calories you burn, the more weight you lose.
When we lose weight by dieting alone, we lose fat while retaining muscle mass. With exercise, you can better retain or gain muscle, while losing fat.
In theory, losing weight is a very simple thing. The basis of weight loss is whether you can stick to the above mentioned. Losing weight is also very difficult. There are always people who cannot be strict with themselves, and give up halfway leading to weight rebound. There are also people who cannot accept losing weight too slowly and pursue fast ways of losing weight. Three popular weight loss peptides (Semaglutide, Tirzepatide, Retatrutide) offer a new way for many obese people to lose weight.

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How to boost testosterone levels ? SERM is better than TRT
More and more people are aware of the possible effects of a gradual decline in testosterone levels with age and are looking for ways to boost their testosterone levels. Testosterone supplements are the most established and effective way to boost testosterone, and many people are trying to get TRT(testosterone replacement therapy). However, in addition to TRT, SERM is also an effective way to boost testosterone levels.
Because the FDA removed TRT from the list of indications to include age-related hypogonadism, this may have caused anxiety in some people about not being able to access a source of testosterone. Actually, there are better ways to boost testosterone than trt.
Hypogonadism is divided into primary hypogonadism and secondary hypogonadism. Primary hypogonadism is usually caused by testicular injury or dysfunction in patients with low testosterone and high LH(luteinizing hormone) levels. Secondary hypogonadism is usually due to the destruction of the HPTA(hypothalamic-pituitary-testicular axis), and often patients present with low testosterone levels and low LH levels.
The decline in testosterone levels associated with increasing age is associated with HPTA and manifests itself in lower LH levels and lower testosterone levels.
For bodybuilders, it is also due to testosterone suppression that leads to low endogenous testosterone levels and reduced LH secretion.
Therefore, this group belongs to the lower testosterone levels associated with HPTA. If you choose Trt, supplementing exogenous testosterone to replace the role of endogenous testosterone will further suppress the production of endogenous testosterone. Although the total testosterone level has gone up, none of this testosterone is secreted by the body. Over time, the body will mistakenly believe that it does not need to secrete testosterone to maintain sufficient testosterone levels in the body, resulting in the shutdown of HPTA.
Using SERM is different. Serms are not androgens, but estrogen receptor modulators. In response to the negative feedback effect of estrogen, the HPTA axis tells the brain to stop secreting LH to stimulate the production of testosterone in the testis. If SERM blocks the action of estrogen on HPTA, it can promote the continuous secretion of testosterone. Therefore, the use of SERM increases the level of testosterone, which is the body's secreted hormone. Not only does this increase testosterone levels, but there is no testosterone suppression due to TRT.
In summary, if the body is still secreting testosterone normally, although still at a low level, it indicates that your HPTA is still working normally, and using SERM can increase testosterone levels. The commonly used SERM is Clomifene, and Enclomiphene is considered more effective by some users. If you still want to maintain the ability of your testicles to produce testosterone, choose to use SERM, unless you are going to use foreign testosterone (TRT) for life.

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Enclomifene vs Clomifene in PCT, is enclo works better?
The formula for PCT is Clomid+Nolvadex, where Clomid stimulates the release of endogenous testosterone and Nolvadex eliminates the effects of estrogen. However, an experienced bodybuilder would choose Enclomifene over Clomifene, and why?
What is Enclomifene?
Enclomifene used by Bodybuilders stands for Enclomifene citrate, or simply enclo. Enclo, like Clomid, is a non-steroidal SERM(selective estrogen receptor modulator). Both work by antagonizing the estrogen receptor in the pituitary gland, reducing the negative feedback effect of estrogen on HPGA(hypothalamic-pituitary-gonad axis), thereby increasing the release of LH(luteinizing hormone) and FSH(Follicle-stimulating hormone), and promoting the production of testosterone.
Enclo vs clomid
Enclo is actually one of the two isomers of Clomid. Clomid itself is equivalent to 38% Zuclomifene and 62% enclomifene. Of the two isomers, zuclo is an estrogen receptor agonist and enclo is an estrogen receptor antagonist, and they play opposite roles.
Since clomid has a half-life of 5 days, enclo has a half-life of about 10 hours, and zuclo has a half-life of 30 days, using Clomid to stimulate the release of testosterone in the daily oral dose is equivalent to stacked zuclo, resulting in zuclo still exerting its estrogen effects after the drug is finally discontinued. Estrogen side effects for users.
The use of anti-estrogen Nolvadex is to eliminate the estrogen produced by the action of testosterone with aromatase, and when combined with Clomid for pct can eliminate the estrogen effect produced by zuclo.
enclo is considered to be more effective than clomid in stimulating testosterone release in men because it does not cause estrogen problems when used directly.
In PCT, boosting testosterone production and eliminating estrogen side effects are usually done at the same time, so there is no problem with using Clomid+Nolvadex. If you only consider the promotion of testosterone production in the testes and the increase of endogenous testosterone levels, Enclomifene is more effective.
When to choose Enclomifene?
Enclomifene is still being studied, and Clomifene has long been approved by the FDA and is a market-proven SERM. Enclo is recommended by many people who have actually used it, believing that it works better. That's right, if you don't need to think about dealing with estrogen side effects, choose enclomifene better. You can also choose the general formula: Clomid+Nolvadex.

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You shouldn’t use HCG in PCT if it is in your cycle
HCG can be used in both PCT and cycle, however, it cannot be used in cycle and PCT at the same time. Why? That's our topic for today.
To understand why HCG can't be used in both cycle and pct, you first need to understand what role it plays in cycle and PCT.
HCG in cycle and PCT
When bodybuilders use high levels of AAS to build muscle, large amounts of exogenous AAS trick the brain into thinking that the body already has sufficient levels of testosterone to stop producing GnRH(gonadotropin-releasing hormone), Without GnRH, the pituitary gland stops releasing LH, and testosterone production is dependent on LH stimulation, so high levels of AAS shut down endogenous testosterone production.
HCG mimics the action of LH(lutein hormone) to promote the production and release of testosterone in the testicles. When use HCG in cycle, hcg helps maintain the ability of the testicles to produce testosterone during the cycle. When use HCG in pct, which is affected by androgen and estrogen levels in the body, LH is not immediately produced and it helps restart the testicles' ability to produce testosterone. Therefore, regardless of whether hcg is used for cycle or PCT, it replaces the role of LH, promotes the production and release of testosterone, and helps maintain endogenous testosterone levels.
What would happen if I continue using HCG in PCT after using in cycle?
The main purpose of PCT is to stimulate the testicles to produce testosterone and eliminate the possible side effects of estrogen, both of which can also be prevented during the cycle, the use of HCG during the cycle to maintain endogenous testosterone production, and the use of AI(aromatase inhibitors) to solve the possible effects of estrogen in advance. The separation of building muscle and solving side effects is called "cycle" and "post cycle" in order to separate goals from solving possible side effects of achieving goals. Focus on building muscle in cycle and solve side effects completely in post cycle. Producing while solving may affect the outcome of the cycle.
Therefore, the post cycle is to completely solve the side effects, because hcg is used in the cycle, if it is still used in the post cycle, it will affect the recovery of the HPTA axis, and the testosterone produced by the testis may not come from GNrH-LH-testosterone, but from the LH analog-testosterone. Therefore, if HCG is used in cycle, there is no need to use it in PCT.
HCG is precisely for PCT, and bodybuilders choose to use it in cycle for one of the most immediate reasons, to prevent testicular atrophy. Because if the cycle is too long, the production of endogenous testosterone is turned off for a long time, according to the principle of "use or lose", the testicles do not exercise the mission of producing testosterone for a long time, and will gradually degenerate and appear as "smaller". Therefore, it is necessary to maintain the function of the testicles during the cycle to prevent atrophy. This is a problem that occurs in the case of a long cycle length, and normal cycles do not need to worry about this problem. Therefore, in the normal cycle, HCG can be used for cycle or PCT, if the cycle is too long, you need to consider adding it to the cycle. In either case, however, HCG is not present in both a person's cycle and the PCT.

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Can I make my own MK677 solution?
All Sarms are orally, and there are two ways of taking them, pills and solution. Most sarms are used in the form of pills, and sarms in liquid form are gradually sold by merchants. Mk677 is one of the earliest sarms in liquid form. The common Mk677 solution is 25mg/ml, which means 1ml liquid content of 25mg mk677.
The dose of Mk677 for women is usually 10mg/day, and the dose of mk677 for men is 25mg/day, so 25mg/ml of mk677 is obviously developed for men, and if the dose for men is 25mg/day, then 1ml per day is the dose required for the day.
As for the dosage of MK677, previously analyzed, the most safe and effective dose without side effects ranges from 10 to 25mg/day, with the highest dose reaching 50mg/day(usually not recommended). While the user tends to test the effects and tolerability of mk677 from the lowest dose, it is more difficult to obtain a suitable dose from the mk677 solution. So, can I configure my own Mk677 solution according to my own dosage? It is possible to configure the mk677 solution yourself.
MK677 is soluble in water
First of all, MK677 is water-soluble and can even be dissolved directly in drinks. Some people may use DMSO, PEG or something else to dissolve MK677, which seems very professional, but in fact, dissolving in water is the easiest way to do it.
Mk677 powder solubility in DMSO is 92mg/ml.
Mk677 powder solubility in Water is 92mg/ml.
Mk677 powder solubility in Ethanol is 92mg/ml.
It is more cost-effective to configure the MK677 solution yourself
On the other hand, the 30ml mk677 solution(content 25mg/ml) is priced from 50-80USD, which is much more expensive than the mk677 raw powder(about 90usd for 10g). Therefore, it is more cost-effective to configure the MK677 solution yourself.
Dissolve yourself for easier dosage control
When purchasing MK677 solution, it involves the relationship between solvent volume and solubility, and it is also necessary to consider whether there will be precipitation problems. Once there is precipitation, the mk677 content in the measured 1ml solution is not equal to 25mg/ml. If you are going to start with mk677 at a dose of 10mg/day, it is difficult to accurately obtain 10mg of mk677 from a solution of 25mg/ml. If you prepare your own MK677 solution, you can take any amount of MK77 and dissolve it in either solution, water, drink or in your dinner. If you don't have the tools to measure the exact weight at home, you can even ask your supplier to do it for you - provided, of course, that your supplier is willing to do it.

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Will MK677 methylated ghrelin receptors change the gene and pass it on to their children?
Recently, a discussion that MK677 methylation brings some epigenetic effects on genes and can be passed on to future generations has caused panic among many users, and today, we will also discuss it.
Is methylation good or bad?
First, let's look at the word methylation. Methylation is -CH3, which normally means replacing hydrogen atoms with methyl groups. Is methylation good or bad?
Methylation is the basis of human metabolism, including cell detoxification, neurotransmitter synthesis, cell growth, tissue repair and gene expression. So, methylation is an essential chemical reaction in the human body. Whether methylation is good or bad depends on whether it is in balance in the body.
Among steroids, methylated compounds are more common, because methylated compounds are generally toxic to the liver, so we can easily list methylation steroids, such as methasteron (superdrol), metandienone (dianabol). MK677 is not actually hepatotoxic.
Epigenetic inheritance
Epigenetics refers to changes in gene expression or cell phenotype that can be preserved and transmitted to offspring through certain mechanisms or pathways when the DNA sequence is unchanged.
However, epigenetic changes are not permanent; they are reversible.
In the case of cancer, for example, genetic changes in cancer patients are not passed on to future generations, however, descendants of cancer patients often perceive a higher chance of developing cancer. This is thought to be a form of epigenetic inheritance, in which a patient's offspring may not develop cancer, but are more likely to develop cancer if they develop the same triggers as their parents.
Similarly, if the parents love sports and get muscle through bodybuilding, then the offspring are more inclined to build muscle easily. However, when he was born, he was still a normal child, and if he did not exercise, he would not gain muscle. In fact, each person has a different degree of difficulty in acquiring muscle, and in the end, it may be that the person who has a harder time acquiring muscle has more muscle because he has worked harder.
What changes will MK677 methylated ghrelin receptors bring to children? Makes them more prone to hunger? Compared to the muscle mass you gain, this may not be a big impact. In fact, most epigenetic inheritance occurs only during an individual's lifetime and does not affect germ cells and is passed on to the next generation.
Should I use MK677?
For example, junk food is bad for your health, smoking can cause cancer, but with junk food everywhere, people still don't give up smoking. The use of supplements to build muscle, whether sarms or steroids, can certainly affect the user, any drug instructions list a long list of side effects, depending on the individual's choice. If I want to use MK677, I need to evaluate the gains and losses for myself, what will I get? At the cost? Do I accept it?

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Retatrutide: Why should I buy a weight loss drug that's still in trial?
Many people are concerned about the latest weight loss product Retatrutide, and some people are already using it to lose weight. However, Retatrutide is still a drug under trials, so why use it for weight loss?
Weight loss effects of Retatrutide
As a three-receptor agonist, Retatrutide's weight loss effect was demonstrated in its Phase 2 trial. After 48 weeks of Retatrutide, the average weight loss was 24.2% (57.8 pounds), and the treatment effect was dose-dependent. The effect reducing weight is better than Tirz and Sema
The three receptors are GLP-1(glucagon-like peptide-1) receptor,GIP(gastric inhibitory peptide) receptor, and GCG(glucagon) receptor.
100% Patients using Reta lost at least 5% of their body weight and 85% patients using Tirz lost at least 5%. This data shows that some users may be ineffective when using Sema or Tirz, and if they use Reta, they will definitely achieve weight loss.
The mechanism of action of GLP-1 and GIP slows down stomach emptying and the rate at which food passes through the digestive system is slower, which means you get full quickly and stay full for longer. In addition to slowing stomach emptying, they also target the hunger center of the brain. The addition of glucagon promotes weight loss in another way. When you're sleeping or haven't eaten for hours, your body still needs energy to survive. Without new carbohydrates converted to glucose, the body breaks down stored sugar to provide the energy the body needs. When the body is free of glycogen, GCG shifts our fat stores, breaking down fat for energy. This is why Retatrutide loses weight faster and more than Tirz and Semaglutide.
Why use the weight loss drug Retatrutide in the trial
As mentioned earlier, Retatrutide is more effective for weight loss and is 100% effective if weight loss is not achieved with Tirz and Sema.
There are concerns about its safety. Retatrutide has completed a phase 2 trial and is now in a Phase 3 trial, which is also looking at obese or overweight patients with knee osteoarthritis, type 2 diabetes, cardiovascular disease and other diseases. This is a different trial model than Semaglutide and Tirz, which are both prioritized for the treatment of type 2 diabetes and approved by the FDA for the treatment of type 2 diabetes before weight loss trials. There are a few years between FDA-approved treatment for type 2 diabetes and weight loss. Retatrutide did not prioritise its treatment of type 2 diabetes, but weight loss was carried out alongside diabetes, showing the team's confidence in it in addition to its better weight loss results.
Am I getting real Retatrutide?
In addition to safety concerns, the availability of real Retatrutide is a key consideration. Some buyers said that the Retatrutide he bought was found to be AOD9604 after testing, while others said that Retatrutide is still in trial and it is not possible to buy real Retatrutide. In fact, once the molecular formula and molecular structure of Retatrutide are determined, you can chemically synthesize the real Reta, and how to synthesize it is really a matter for chemists and laboratories, you just need to test whether the Reta you buy is Retatrutide. If you detect AOD9604, then you are actually deceived, not because the real Reta cannot be synthesized.
Astersteroids provides real Retatrutide, subject to testing, guaranteed quality, welcome to inquire and purchase. If you are still on the fence about Retatrutide, you may choose to continue using Semaglutide or Tirzeptide if they still help you lose weight.

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Stack weight loss peptides Semaglutide Tirzepatide Retaturtide would have better effects?
From GLP-1 receptor agonists, to GLP-1 and GIP double receptor agonists, to GLP-1,GIP and GCG triple receptor agonists. Let's say you are using Semaglutide to lose weight and a new peptides come along and it is reported that the new weight loss peptides are better at losing weight than Semaglutide, will you switch from using Semaglutide to using the new peptides. If Semaglutide doesn't work for you, you may be willing to try a new peptide. If Semaglutide works so well for you, would you be willing to try a new weight loss peptide? The same is true for Retaturtide.
When the peptide I was using worked well, it was very heartwarming to report that the new slimming peptide worked even better. A lot of people are getting excited, so a lot of people are focusing on how to switch from an old peptides to a new one. Others, however, are more direct: If I'm not sure which one is better, I'll just keep using it. So, is it better to combine three weight loss peptides, Semaglutide, Tirzepatide and Retaturtide?
Semaglutide Tirzepatide Retaturtide stack astersteroids.com/stack-weight…
Sema, Tirze and Reta all act on GLP-1 receptor. In addition, Tirze has one more GIP receptor than Sema, and Reta has one more GCG receptor than Tirz. When the three are used in combination, they are actually equivalent to Retaturtide in the acting receptor. And because stacking is used, it is equivalent to increasing the dose, because the acting receptor is different, and the final result is about a partial increase in the acting effect of Reta.
In this case, it is only necessary to simply increase the dose of one of the weight-loss peptides being used, and there is no need to stack. Some users have raised a price issue, Sema's price is lower, and stacked use can control costs. This is a very practical direction, however, the choice of this stacking method, obviously because the latter effect is better, want to achieve a better weight loss effect, but also to control the cost, chose this way. This use proves laterally that Semaglutide, Tirzepatide and Retaturtide can be stacked.
However, the vast majority of people still choose to use a single peptide to lose weight if the peptide he is using can achieve good weight loss results. Some people use these three peptides in rotation, users think that the weight loss effect is also very good. So, is it necessary to switch them frequently?
Users believes that if you switch between multiple peptides, it will increase the life of the drug and help the drug to develop tolerance later, which is not yet proven. The basis may be that in the study, when the weight loss reached a plateau, the drug stopped for 3 months, and then resumed, the weight began to drop again.
In conclusion, Semaglutide, Tirzepatide and Retaturtide can be stacked, but it is still uncertain whether the effect will be better after stacking. Of these three weight loss peptides, Reta appears to be the most effective at present, and the mode of action of the other two peptides is contained in Reta. The effect of stacking is not changed much, and it may also bring the side effect of excessive GLP-1 receptor agonist.

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Semaglutide Tirzepatide Retatrutide Overview of three weight loss peptides
The three most widely talked about peptides are Semaglutide, Tirzepatide and Retatrutide . Of the three peptides, Semalutide is the most widely used weight loss peptide, while Retatrutide is the latest. Today, let's compare these three peptides.
Semaglutide Tirzepatide Retatrutide mode of action
Semaglutide is a GLP-1 receptor agonist;
Tirzepatide is a double receptor agonist of GIP and GLP-1.
Retatrutide is a triple receptor agonist for GIP, GLP-1 and GCG.
Only from the perspective of the mode of action of Semaglutide Tirzepatide Retatrutide , Semaglutide is more simple and Retatrutide is more extensive. So, is Retatrutide better?
Whether Retatrutide is better or not depends on where you evaluate it. If you look at weight loss alone, it is really the best. Here are their weight loss stats.
Semaglutide Tirzepatide Retatrutide weight loss data
The average weight loss after 68 weeks of Semaglutide was about 15 percent (34 pounds);
The average weight loss after 72 weeks of Tirzepatide was about 22.5% (52 pounds).
The average weight loss of Retatrutide after 48 weeks of use was about 24.2 percent (57.8 pounds).
Only from the experimental data, Retatrutide has a better weight loss effect, among which, the weight loss data of Tirzepatide is close to Retatrutide , but it is important to note that Tirzepatide is used after 72 weeks, while Retatrutide is used after 48 weeks. So, obviously, Retatrutide loses more weight and loses weight faster.
So, when Semaglutide Tirzepatide Retatrutide is compared together, is Retatrutide directly chosen?
Semaglutide Tirzepatide Retatrutide Approval
In fact, more people lose weight using Semaglutide than Retatrutide . It has to do with whether it gets FDA approval or not.
Semaglutide was first approved by the FDA for the treatment of type 2 diabetes in 2017, and then officially approved by the FDA for weight loss in 2021.
Tirzepatide received FDA approval for the treatment of type 2 diabetes in 2022, followed by clinical trials for weight loss, still awaiting FDA Approval for weight loss.
Retatrutide , which is directly focused on weight loss, is not being developed to treat type 2 diabetes as a priority, but rather to treat type 2 diabetes and lose weight in several trials simultaneously. The developers' confidence in Retatrutide can also be seen here.
Semaglutide Tirzepatide Retatrutide review
By comparing the three peptides Semaglutide Tirzepatide Retatrutide , we can see that Retatrutide is one of the peptides that loses weight faster and more weight, but it is still waiting for FDA approval. Semaglutide and Tirzepatide are currently used by more people, and if these two peptides can help you lose weight effectively and sustainably, congratulations. Depending on your physique and tolerance, if you use these two weight loss peptides and find that the effect is not ideal, then Retatrutide is your hope. Experimental data of Retatrutide have demonstrated that it is an excellent weight loss peptide.

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Growth hormone releasing peptide Hexarelin Acetate increased HGH levels
Like Tesamorelin and Sermorelin acetate, Hexarelin Acetate is also used to increase the levels of growth hormone (HGH). In this article, we will delve into Hexarelin Acetate and its role in raising HGH levels.
What is Hexarelin acetate peptide?
The growth hormone releasing peptide Hexarelin acetate works by stimulating and activating the growth hormone secretagogue receptor in the brain, promoting growth hormone release and increasing HGH levels.
Hexarelin acetate is one of the growth hormone-releasing hormones. However, unlike Tesamorelin and Sermorelin, hexarelin acetate is not derived from GHRH, and its structure is closer to GHRP-6.
Human growth hormone (HGH) is an important hormone produced by the pituitary gland. It plays a vital role in cell growth, regeneration and overall health. As we age, the production of growth hormone naturally declines, leading to a variety of age-related health problems. Hexarelin acetate works by stimulating the release of HGH in the body, which may have a number of benefits.
Enhance muscle growth and repair
One of the most sought-after effects of raising HGH levels is the potential for enhanced muscle growth and repair. Growth hormone helps increase the synthesis of new proteins and promotes the growth and repair of muscle tissue. This is especially beneficial for athletes and bodybuilders who want to gain a competitive edge and recover more quickly from strenuous exercise.
Reduce body fat
Hexarelin acetate has also been linked to its potential for fat loss. Higher levels of growth hormone can promote the breakdown of fat cells, which is an attractive option for individuals seeking to control body composition and reduce excess fat.
Improves energy and endurance
As HGH levels increase, individuals usually experience an increase in energy and endurance. This is especially beneficial for athletes and people engaged in physically demanding activities. Increasing energy levels can lead to more productive workouts and better overall performance.
anti-aging
While Hexarelin acetate isn't a panacea for immortality, its ability to boost HGH levels has sparked interest in its potential anti-aging effects. Higher HGH levels are associated with improved skin health, enhanced cognitive function, and better overall vitality.
Hexarelin Acetate review
Hexarelin Acetate is a synthetic peptide that has garnered attention for its potential to boost growth hormone levels in the body. Increased HGH levels may confer several benefits, including improved muscle growth and repair, reduced body fat, improved energy and endurance, and potential anti-aging effects.

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Semaglutide:What to do if you still can't lose weight after exercise?
Losing weight can be said to be one of the most popular topics in contemporary society. Some people lose weight for an attractive appearance, while others lose weight for a healthier body. The two most common ways to lose weight are to control your diet and participate in exercise. These two ways can help lose weight, but after the weight is reduced to a certain extent, then participate in sports, there may be a problem that the weight can not be further reduced, at this time, how to do?
One woman had this problem: ”I have worked out like a crazy person for years. Hired a health coach, counted macros. Cut carbs. You name it I have tried it. I lost 20 lbs on my own after baby #3 and plateaued for close 2 years.”
She tried a diet plus exercise regimen to lose weight, but after losing 20 lbs, the weight loss stalled.
How did she solve the problem later?
"2.5 weeks in Semaglutide and B12 shots I am down 9.5 lbs!
No more stressing stepping on the scale every morning. Not only do I feel great but the years of built up stress from not being able to shed the weight is gone. ”
Immediately after Semaglutide was recommended, the weight began to drop, and her anxiety stopped and she began to become confident and optimistic.
How does Semaglutide lose weight?
How does Semaglutide achieve fast and effective weight loss? It was originally developed as a treatment for type 2 diabetes, and later the FDA approved slightly higher doses of Semaglutide for weight loss. Semaglutide is a GLP-1 receptor agonist that works by mimicking the action of GLP-1. It achieves weight loss by regulating blood sugar, slowing stomach emptying, and controlling appetite.
The principle of weight loss is simple: eat fewer calories than you burn. But enforcing this principle is difficult. Either have no time to exercise, or can't control the desire to eat. Semaglutide users say: “It as a drug for addicion due to that food noise thing for people with eating disorders.””I can go go social events and not worry about eating too musch or not being able to control myself. I used to avoid social situations because I would always binge. I also go out to eat again without any guilt because I’m able to eat smaller portion sizes.”
So, use Semaglutide, you’re easy to control yourself to lose weight.
#3

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What should I do when I experience nausea with Semaglutide?
It's easy to say that Semaglutide helps users lose weight by suppressing appetite and increasing satiety, but Semaglutide's ability to do so is anything but simple. It strictly controls your appetite, so that you will not eat too many calories, so as to achieve the purpose of weight loss. However, some people who use Semaglutide experience nausea , and today we will discuss how to resolve or relieve these symptoms.
“I felt great this morning, went out to run some errands and then out of nowhere, nausea hit me. I may or not have thrown up in my purse while I was on the highway.”
This is how a Semaglutide user really feels, and it can happen in the course of using Semaglutide. But the fact that they might happen is not to say that it's the norm, they happen for a reason. In fact, this may be related to two situations, one is the user using more than the dose of Semaglutide, and the other may be due to excessive dieting.
As reported in Semaglutide trials, nausea and vomiting may occur when the dose of Semaglutide is increased from the initial dose to the target dose, so excessive use of Semaglutide should be ruled out first when nausea and vomiting occur.
Plus, Semaglutide is so effective at losing weight that you'll probably wake up to a new (and thinner) version of yourself every day. Some people are eager to see results, thinking that Semaglutide has made them unable to eat more food, and without the desire to eat, they simply stop eating, thinking that they will lose weight faster. Of course, this will lead to faster weight loss, but the nausea will be aggravated, and proper eating will be a good way to alleviate or resolve this symptom.
If you're feeling like you don't want to eat at all, try this recipe recommended by an avid Semaglutide user, a meal replacement that helps fuel your diet without putting on weight or throwing up:
3/4c Twogood Vanilla Greek Yogurt: 13g protein.
1c Dark Chocolate Silk: 1g protein.
2C Organic Super Greens: 2g protein
1 frozen/raw banana: 1.3g protein
2T All Natural peanut butter: 8g protein.

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How to deal with the most common appetite problems when use Semaglutide to lose weight?
Semaglutide is a very popular weight-loss peptide that works to lose weight by suppressing appetite, increasing satiety, and boosting metabolism. When using Semaglutide, the most common symptoms of appetite related side effects are actually related to its weight loss mode. When you use Semalutide to lose weight, how do you deal with the associated side effects?
Loss of appetite In Semaglutide
When an obese person is trying to lose weight, it is hard to resist the urge to eat. Especially when you are in the process of dieting, often feel very hungry, this sense of hunger will make you crazy to eat. When you eat a large amount of food, hunger is eliminated, and you are feeling satisfied with your stomach, only to find that you have eaten an excessive amount of calories, and the little weight loss that you have worked hard for several days is instantly wiped out.
Semaglutide has no such concerns at all, and from the comments of some people who are using Semaglutide to lose weight, you can probably see how quickly they can lose weight.
“Bag of cheetos left untouched for a week.”
What is the feeling of fullness that makes a bag of snacks sit in front of you for a week without the desire to eat it?
“Hungary, I couldn’t wait to eat... then full after barely 5 bites.”
-- When you feel very hungry, you can't wait to eat 5 bites and then you are full. under the condition of using Semaglutide to lose weight, you no longer have to worry about accidentally overeating. Under the condition of using semaglutide to lose weight.
“I chew one last bit of something that tastes good and have to spit it out because I just can’t make myself swallow it.”
-- Want an extra bite? You can’t do it, your body said it was the last bit.
Seeing the real feelings of the above users, I believe you can understand why Semaglutide is popular. In the course of using Semaglutide, it will strictly control your appetite, increase your feeling of fullness, so that you can not eat excess calories. This is the most basic operation of all weight loss methods, anyone knows they should do it to lose weight, they just can't do it themselves, and Semaglutide helps you do it.

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Anabolism and muscle building for bodybuilders
Some Bodybuilders will try to use steroids to help build muscle, the full name of which is anabolic androgenic steroids. There are also people using Sarms, and the advantage of sarms over steroids is that they only have anabolic activity without androgen activity. There are also peptides, which all mention their anabolic activity when bodybuilders use them. Therefore, there is a direct relationship between anabolism and muscle growth.astersteroids.com/anabolism-an…
What is anabolism?
Anabolism is a type of metabolism.
Metabolism is a general term for the orderly series of chemical reactions that occur in living organisms and are used to sustain life. These reactions allow them to grow and reproduce, maintain their structure, and respond to their environment. Catabolism refers to the decomposition of the original part of the organism to release its energy; Anabolism is the process by which organisms convert nutrients from the environment into their own components and store energy.
Anabolism and muscle building
Everyone's metabolism is different, and body size, age, gender, and genetics all affect it. However, muscle requires more energy to maintain than fat cells, so people with more muscle usually require more energy, i.e. have a higher metabolism. On the other hand, people with more fat than muscle have a slower metabolism.
In the growth and development stage, more substances are needed to build their own bodies, so the metabolism is strong, and anabolic action is dominant. As we age and our metabolism slows down, we naturally begin to gain fat and lose muscle. Because of this, the metabolism slows down, it becomes difficult to lose weight and gain muscle.
People with more muscle have a higher metabolic rate and therefore require more energy to maintain. With the increase of age, the metabolism will gradually decrease, so it is not conducive to the reduction of fat and the increase of muscle.
When a person's metabolic level is increased, its anabolic level and catabolic level are increased at the same time. However, anabolism promotes the production of muscle, and catabolism promotes the breakdown of muscle (muscle first, fat later), so is it contradictory? Anabolic steroids, or sarms, or peptides, mainly promote muscle anabolism, and protect muscle tissue during the process of catabolism, giving priority to the decomposition of fat for energy. This is the key reason why they build muscle and lose fat. In this process, you need to eat enough food and get enough exercise to improve your metabolism.

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The anti-aging effect of muscle building Peptides Sermorelin acetate
Aging, the most common is external changes, including skin deterioration - wrinkles, body shape changes - becoming fat, etc., including internal performance including fatigue, weakness, etc. Aging is also sometimes related to the length of life, people always think that people who look younger, should have a longer life. People are always looking for new ways to combat aging, and Sermorelin acetate is a popular anti-aging peptide.
The anti-aging effect of Sermorelin acetate is based on its ability to stimulate the secretion of natural HGH, which is a popular product for mature anti-aging products. Compared to HGH directly raising the user's HGH level, Sermorelin acetate raised its own HGH level by stimulating the release of natural growth hormone without raising HGH beyond the physiological range. That is, the beneficial effects of elevated HGH levels can be achieved without the side effects that may be associated with hyperphysiological levels of HGH.
Growth hormone levels in adults decline with age, and the symptoms of aging appear, including poor skin condition, wrinkles, low energy, reduced libido, weakened immunity, and decreased muscle and bone mass.
The source of skin problems is mainly due to the reduction of cell number, cell water loss, collagen loss, cell elastic fibrosis and other causes. Cells constitute the basis of the human body, the main role of HGH is to stimulate cell reproduction and cell regeneration, it helps to produce high-quality new cells to replace the body's natural aging or death of the old cells, so as to maintain young function.
With age, muscle mass is more difficult to maintain, and fat is easier to produce and accumulate, body shape change is a very intuitive aging phenomenon. HGH has the effect of regulating body composition, it promotes the burning of fat to provide energy for the body, promotes the synthesis and retention of lean muscle, thus avoiding the accumulation of fat, while retaining lean muscle mass.
HGH increases the level of human metabolism, making people more energetic and willing to participate in physical exercise activities. It also AIDS sleep, benefits bone health, enhances recovery, and boosts libido. Compared with the use of HGH directly,Sermorelin acetate stimulated the pulsing secretion of HGH, simulating the normal timing and energy without affecting the neuroendocrine axis of natural growth hormone. Thus maintaining youthful physiology.

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Under what circumstances should you consider Sermorelin acetate use?
Sermorelin acetate is a type of GHS(growth hormone secretagine) that helps to raise the levels of autocrine growth hormone (HGH), so that when you experience symptoms related to a decrease in GH, You may want to use Sermorelin acetate or other methods to help boost HGH levels.
In addition to low HGH levels that may occur due to physical reasons, normal HGH levels in adults also gradually decline with age, and studies have shown that from the age of 30, HGH produced by the body drops by 24% every decade. What are the common symptoms of low hgh levels?
Girth enlargement
The most common age-related change is an increase in waist circumference, and "middle age" is often associated with a "big belly," in addition to being associated with decreased levels of sex hormones, but also due to decreased levels of HGH. And an increasing waist circumference over the years is likely to mean a sharp decline in HGH. Anabolic peptides HGH helps improve the composition of the body, which includes fat loss and lean muscle mass increase, especially for stubborn fat such as the abdomen, HGH is very effective. Using Sermorelin acetate helped restore normal levels of HGH.
Decreased strength and endurance levels
Decreased strength and endurance levels can be due to increased fat, decreased muscle mass and bone loss, which can make your exercise program difficult to sustain. peptides HGH can improve human metabolism, increase exercise ability, and prevent muscle loss and bone loss. It burns fat to provide energy to the body and helps to better participate in physical exercise.
Decreased libido
Decreased libido is also one of the phenomena of decreased HGH levels. Studies have shown that patients treated with Sermorelin acetate have a more active sex drive compared to normal people.
Insomnia and decreased sleep quality
Sleep problems are a common age-related problem associated with changes in the body's hormone levels. As we age, the quality of sleep decreases, and most of the body's growth hormone is produced during sleep. When a person's sleep quality decreases, it affects HGH levels. As HGH levels get lower and lower, you may experience insomnia. Sermorelin acetate can increase the level of HGH, and it is also conducive to sleep, helping users to improve the quality of sleep.
Skin problem
Skin problems are a reflection of age and an external sign of reduced HGH levels. The anti-aging effect of HGH helps to tighten the muscles under the skin, reduce wrinkles and excess fine lines on the face and body, and increase the elasticity of the skin.

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Growth hormone releasing hormone Sermorelin acetate vs Tesamorelin, which is better?
Compared with the different action modes of Sermorelin acetate and HGH, the action modes of Sermorelin acetate and Tesamorelin could be said to be exactly the same. Sermorelin acetate and Tesamorelin are both analogues of growth hormone releasing hormone (GHRH), and both work by stimulating the synthesis of HGH(growth hormone). So how do I choose between these two peptides?
Different structure
The most direct difference between Sermorelin acetate and Tesamorelin is that both of them are derived from the structure of GHRH, in which Sermorelin acetate intercepted 29 amino acid sequences of GHRH and retained the ability of GHRH to stimulate HGH release. Tesamorelin has all 44 amino acid sequences of GHRH.
Different indication
peptides Sermorelin acetate and Tesamorelin acetate were studied and developed to treat corresponding diseases, among which Sermorelin acetate was mainly used to treat HGH deficiency in children and adults. Tesamorelin is primarily used to treat excess abdominal fat in HIV patients with lipodystrophy.
From their indications, it can be seen that Sermorelin acetate has a different emphasis than Tesamorelin, which provides guidance on how to choose them.
When to choose Tesamorelin?
Tesamorelin is mainly used to reduce excess abdominal fat accumulation, so you should choose Tesamorelin when your main purpose is fat loss. HGH has the effect of altering body composition (reducing fat, promoting lean muscle mass gain), and in cases where body fat mass is evident, the use of Tesamorelin helps to reduce fat quickly. However, Tesamorelin acts through HGH, and in addition to reducing fat, it also has the benefits of HGH, including improved metabolism and protein synthesis, increased lean muscle mass, faster healing, and improved athletic performance.
When do I choose Sermorelin acetate?
Sermorelin acetate is mainly used for HGH deficiency, therefore, the benefits of using Sermorelin acetate are the benefits of HGH, except that Sermorelin acetate increases the level of autocrine HGH and does not increase the level of endogenous HGH to a superphysiological level. When bodybuilders use Sermorelin acetate, the main effect is to improve lean muscle mass, that is, to increase muscle mass while avoiding fat accumulation.
Thus, Sermorelin acetate could be used when bodybuilders aim to increase metabolism and build muscle, or Tesamorelin acetate if they focus on fat reduction or cutting.

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Sermorelin acetate vs HGH to increase GH level, which one is better?
The effect of Sermorelin acetate vs. HGH is similar. What is the specific situation and which one is more effective?
The same effects of Sermorelin acetate vs HGH
HGH is human growth hormone and is an anabolic peptide. It is regulated by growth hormone-releasing hormone (GHRH) secretion and stimulates human growth, cell reproduction and cell regeneration. In adults and bodybuilders, it helps increase metabolic levels and contributes to muscle growth and fat loss, thereby increasing lean muscle mass.
Sermorelin acetate is a type of growth hormone releasing hormone (GHRH) derived from 29 of the 44 amino acids of GHRH, retaining the ability of GHRH to stimulate GH release. Therefore, the use of Sermorelin acetate is mainly to stimulate the release of HGH and increase the level of HGH in the body, so Sermorelin acetate and HGH have similar effects.
The difference of Sermorelin acetate vs HGH
Whether they used Sermorelin acetate or HGH, they all played the role of HGH in the end. The most direct difference between them was the difference in the mode of action, one was to indirectly increase the level of HGH in the body, while the other was direct.
HGH
The use of HGH is to directly add exogenous HGH to improve the overall HGH level of the body, which bypasses the human body's natural HGH production mechanism and improves the total HGH level, but does not improve the secretion of endogenous HGH. Therefore, it does not help the level of autocrine HGH. Even, by the automatic regulation of the human hormone balance, as the level of exogenous HGH increases, the secretion of endogenous HGH may decrease. Therefore, the use of HGH increases the overall level of HGH, increases the level of HGH available to the body, helps to play the beneficial role of HGH, but does not increase the level of autocrine HGH, and may reduce the level of endogenous HGH.
Sermorelin
Sermorelin acetate was used to bind to GHRH receptors to stimulate the secretion of HGH, which acted before HGH production and mimicked the natural production pattern of HGH. Compared with the direct supplement of exogenous HGH, regulated by the balance of human hormone levels, Sermorelin acetate could interact with somatostatin to promote the intermittent release of HGH after entering the human body, which was similar to the production pattern of natural HGH and more friendly to the human body, thus avoiding the possible tolerance reaction caused by the direct use of HGH. Studies have shown that using Sermorelin acetate allows the body to adjust to previous levels of HGH secretion, helping to improve the function of the component itself, rather than simply replacing the effect of HGH that the body is already lacking.
In conclusion, the use of Sermorelin acetate was more in line with the self-regulation of human hormones, and the increased HGH level was within a safe and controllable range. However, if you are after a level of HGH in a superphysiological dose, only exogenous HGH can be done.

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What is Sermorelin acetate,how does it work?
Sermorelin acetate is one of the GHRH(growth hormone releasing hormone) analogues, which has the effect of promoting the release of GH(growth hormone).
What is Sermorelin acetate?
There are two naturally occurring GHRH analogues: GHRH1-40)-OH and GHRH(1-44)-NH2, Sermorelin acetate are truncated GHRH analogues containing 1-29 amino acid fragments of human GHRH, which are considered to be the shortest fully functional fragment of GHRH. Therefore, Sermorelin acetate has a similar effect to GHRH. The FDA approved the peptide in 1997 for clinical use to treat age-related GH deficiency and promote growth in children.
Under natural conditions, Sermorelin acetate is a sterile, pyrogen free white freeze-dried powder that is dissolved and administered by injection under the skin. It has a short half-life of about 11 minutes. However, unlike other peptides, Sermorelin acetate does not need to be injected frequently, only once a day.
How does Sermorelin acetate work?
Sermorelin acetate has a similar effect to GHRH in that it binds to the human GHRH receptor and stimulates the release of GH. Different from direct GH supplementation, Sermorelin acetate stimulated the natural and pulsing release of GH. The effect of this mode of action was similar to that of GHRH stimulated the pulsing release of GH. Therefore, the increase of GH level with Sermorelin acetate was more similar to the increase of natural HGH level in human body. Sermorelin acetate increases HGH levels by acting in a similar way to HGH naturally secreted by the body. By boosting natural HGH levels, Sermorelin acetate promotes muscle strengthening and helps burn fat, thereby altering the user's body composition, leaving the user with more lean muscle and less fat.
peptides Sermorelin acetate was used by bodybuilders because the effects of Sermorelin acetate were similar to those of cutting. In fact, in addition to the above main results, Sermorelin acetate will also increase the endurance level of bodybuilders, increase recovery, maintain bone health, etc.
As well as bodybuilders using Sermorelin acetate, some people are also using Sermorelin acetate to combat ageing. Sermorelin acetate is also known as an anti-aging peptide, and in fact HGH is also used in the field of anti-aging. HGH promotes cell proliferation, increases metabolic levels and protein synthesis, and provides the effect of slowing and reversing aging. The use of Sermorelin acetate can safely increase the HGH levels that decrease with age, without inhibiting their own HGH levels or causing the side effect of HGH overdose.

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Who is using or buying anabolic peptides Sermorelin acetate?
Sermorelin acetate is a synthetic growth hormone releasing hormone (GHRH), which has a similar effect to GHRH, mainly stimulating the release of growth hormone (GH), relieving and treating symptoms related to GH deficiency. So who needs to use Sermorelin acetate?
People who lack growth hormone
The FDA approved the use of Sermorelin acetate for the treatment of children with growth hormone deficiency or growth disorders, including acute or age-related GH deficiency. Therefore, Sermorelin acetate is suitable for people with insufficient GH levels. For minors, it's lack of height. For adults, Sermorelin acetate is used when symptoms associated with low GH levels occur. Symptoms of low GH levels include slowed metabolism, increased fat, depression, lack of strength and endurance, osteoporosis, decreased libido, sleep disturbances, skin deterioration, etc.
People who are fighting aging
Also known as an "anti-aging peptide," Sermorelin acetate has been the subject of numerous studies on slowing and reversing the signs and symptoms of aging. Most of the symptoms caused by low GH levels are related to aging. HGH is the most popular peptide in anti-aging. The level of HGH in human body decreased year by year with the increase of age after 30 years old. Sermorelin acetate simulated the effect of GHRH by binding with GHRH receptor and promoting the release of GH. Compared with the direct supplement of HGH, Sermorelin acetate stimulated the pulse release of GH and helped to restore the normal level of GH without increasing the GH level to the superphysiological level. Therefore, using Sermorelin acetate could help people to safely combat aging.
For bodybuilders
Bodybuilders are also using Sermorelin acetate because Sermorelin promotes the release of GH, which helps to improve the body's metabolic level, increase muscle production and fat loss, as well as helping to increase endurance, aid recovery, and enhance bone health. These features are very useful for bodybuilders. However, its strength is also its weakness, because it does not raise growth hormone to superphysiological levels, so the muscle mass gained from using it will be more limited, and bodybuilders tend to use superphysiological doses of HGH in the process of building muscle. The muscle gained by using Sermorelin acetate was not as much as that gained by using HGH. However, Sermorelin acetate is still useful for bodybuilders, it can be used as an auxiliary bodybuilding supplement, and it works better when it is used with CJC-1295.

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Peptides Tesamorelin benefits in bodybuilding
Tesamorelin acts as an analogue of GHRH, promoting the release of GH and IGF-1, and is an anabolic peptides commonly used by bodybuilders, what are Tesamorelin benefits in bodybuilding?
Reduce belly fat
Tesamorelin can improve fat distribution in patients with lipodystrophy and promote the reduction of abdominal fat. In HIV patients with abdominal fat accumulation, daily subcutaneous injection of 2mg Tesamorelin treatment resulted in a sustained reduction in visceral fat.
In 2010, the FDA approved the use of Tesamorelin to reduce excess abdominal fat in HIV-infected malnourished patients, and experiments showed that the average abdominal fat was reduced by about 18% after 6 months of treatment with Tesamorelin.
Increase muscle mass
Tesamorelin increases skeletal muscle density (reduces fat) and skeletal muscle area, supporting an overall improvement in muscle mass.
In the trial, a significant increase in total muscle density and muscle area in all four trunk muscle groups (rectus abdominis, anterolateral abdominis, psoas major, and paravertebral muscles) was observed by computed tomography (CT) after Tesamorelin treatment.
Improve liver health
For both male and female patients with liver fat accumulation, treatment with Tesamorelin for 12 months resulted in a significant reduction in liver fat. In treatment, Tesamorelin causes a significant increase in creatine phosphate, which effectively protects the liver from hypoxia and impaired blood flow.
Improve blood lipid profile and reduce the risk of cardiovascular disease
Tesamorelin has beneficial effects on triglyceride, total cholesterol, low density lipoprotein and high density lipoprotein. Tesamorelin is used to reduce visceral fat, improve blood lipid and blood sugar status, and reduce the risk of cardiovascular diseases.
Improve cognitive function
Tesamorelin, as an analogue of GHRH, has a significant effect on brain function. For people with age-related memory problems and those with chronic progressive mental decline, Tesamorelin use improves executive function, verbal and visual memory, thinking skills, and neurocognitive abilities.
Treatment of nerve injury
Nerve damage can lead to impaired motor and sensory function in the affected area, and research shows that the use of Tesamorelin can speed up the healing of damaged nerves.

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Use peptides Tesamorelin to reduce abdominal fat
With the growth of age and the gradual decline of metabolism, obesity problems gradually become more prominent. Fat loss is a problem that is related to almost all middle-aged people, among which, how to reduce belly fat is another difficult problem in fat loss. Today, we're going to talk about howTesamorelin can reduce belly fat.
Fat and belly fat
Fat is a way for humans to store food in order to conserve energy. There are many ways to provide energy to the body, mainly sugar and fat. Fat is the most energy-dense, releasing much more energy for the same weight of fat than when sugar is broken down.
When food is scarce, fat storage energy is beneficial to the health of the body, however, in today's material abundance, when the intake of energy is much more than the energy consumed by the body, excess heat continues to accumulate in the body, fat storage gradually increases, forming obesity.
Abdominal fat is the most dangerous type of fat because when it grows in the abdominal area, it surrounds the internal organs. Large amounts of belly fat can put people at risk for a variety of health problems, including heart disease, diabetes, liver problems, and an increased risk of sudden death.
Why use Tesamorelin to reduce belly fat?
Tesamorelin is an FDA-approved treatment for reducing excess abdominal fat in HIV-infected patients with lipodystrophy associated with antiviral therapy. Tesamorelin has also been evaluated as a treatment for insulin resistance, obesity, and non-alcoholic fatty liver disease.
How does Tesamorelin reduce belly fat?
Tesamorelin is a compound modified on the N-terminal of all 44 amino acid sequences of GHRH(growth hormone releasing hormone), which is more effective and stable than GHRH. After Tesamorelin is used, it enters the body and binds to GHRH receptors, stimulating the release of growth hormone (GH). Increased GH levels boost metabolism and improve muscle growth, which helps burn more calories and reduce fat in the body. Tesamorelin also helps increase insulin growth factor (IGF-1), which further stimulates weight loss. Therefore, Tesamorelin helps to reduce visceral fat and improve abdominal appearance, size, and waist circumference.

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Tesamorelin advantages :There are GH and IGF-1, why needs Tesamorelin peptides ?
The benefits of Tesamorelin
Tesamorelin plays a similar role to GHRH by binding to GHRH receptors, stimulating the synthesis and release of endogenous GH. The released GH boosts metabolism and improves muscle growth, helping to burn more calories and reduce fat in the body. Tesamorelin also helps to increase IGF-1 levels, which further enhances metabolic levels and stimulates lipolysis. Especially for parts such as the abdomen where fat is easy to accumulate and difficult to remove, the use of Tesamorelin is better.
In the Tesamorelin trial, after 3 to 12 months of treatment, the subjects' organ fat was reduced by 10 to 20 percent, and the average visceral fat was reduced by 18 percent.
Various experiments targeting Tesamorelin also showed that Tesamorelin treatment reduced fat mass while increasing lean muscle mass. Through changes in trunk muscles based on computed tomography (CT), it was found that compared with the placebo group, all trunk muscle groups of the subjects, Including rectus abdominis, anterolateral abdominis, psoas major and paravertebral muscles, total muscle density and area increased significantly.
Tesamorelin vs HGH
Tesamorelin acts on the front end of HGH, and although it also acts by stimulating the production and release of GH, it has two main advantages over the direct use of HGH.
One is that Tesamorelin is used in the process of reducing abdominal fat, which does not stimulate excessive GH secretion. So it does not bring the side effects of HGH excess.
Second, the direct use of HGH treatment can cause slight impairment of glucose metabolism in patients in a short period of time, while the use of Tesamorelin treatment can significantly reduce the amount of fat in obese individuals without affecting glucose metabolism.

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Tesamorelin is derived from GHRH and promotes the release of GH and IGF-1
Tesamorelin, a synthetic form of growth hormone-releasing hormone (GHRH), was approved by the FDA in 2010 for the treatment of HIV-related disorders of fat metabolism. Because it's approved for reducing belly fat in HIV patients, would we think it could be used for fat loss? And because it has the effect of GHRH, would we assume that it helps to raise GH and IGF-1 levels? So what are the facts, and why do Bodybuilders use Tesamorelin?
Tesamorelin and GHRH
Tesamorelin is derived from GHRH and is based on all 44 amino acid sequences of GHRH, with modifications added at the n-terminal. Tesamorelin is a modified GHRH. This modification increases its plasma stability and reduces renal clearance, making it more stable. It also increases its membrane permeability, making its effect more effective; It also lengthens its cycle half-life.
GHRH is a growth hormone-releasing hormone naturally produced by the human body that stimulates GH secretion by acting on GHRH receptors. GHRH is released as a pulse and stimulates GH pulse release. GH promotes liver secretion of IGF-1 and stimulates gluconeogenesis. GH is essential for maintaining muscle and bone mass and affects fat distribution in the body. Therefore, the effect of Tesamorelin on the human body is similar to that of GHRH, mainly through the action of GH and IGF-1.
Tesamorelin and fat loss
HIV patients after antiretroviral treatment, will affect the distribution of fat in the body, a large amount of fat is deposited in the abdomen, forming typical post-treatment symptoms.
Clinical trials have shown a 10-20% reduction in abdominal fat in patients after 3-12 months of treatment, and it is well tolerated with no side effects associated with GH excess.
Belly fat is often more difficult to get rid of than fat in other areas, and Tesamorelin helps to reduce belly fat in a targeted way.
Why do Bodybuilders use Tesamorelin?
Compared with the direct use of GH or IGF-1, the use of Tesamorelin acts on the front end of GH to stimulate the pulse release of GH, and does not produce the side effect of excess GH, which is relatively safer.

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Does IGF-1 make you bigger?
IGF-1 is an anabolic peptide commonly used by bodybuilders to increase metabolism, promote protein synthesis, and help bodybuilders gain muscle mass. So, obviously, IGF-1 makes you bigger. Not only that, IGF-1 has been shown to stimulate testosterone production in testicular interstitial cells and, together with testosterone, mediate some of the growth-promoting effects of androgens in androgen-reactive tissues. So, in addition to building muscle, IGF-1 really does make you bigger.
Effects of testosterone and IGF-1 on anabolic reaction of foreskin fibroblasts
In the experiment, the culture was exposed to increased concentrations of IGF-1, or to increased concentrations of testosterone in the presence and absence of IGF-1, and the protein synthesis response was measured.
Protein synthesis increased dose-dependent as IGF-1 concentrations increased between 25 and 100ng/mL. Compared with the control, the maximum increase was 34+/-3%, P< 0.001.
In contrast, testosterone concentrations increased between 1 and 1000nm, and in the absence of IGF-1, the results did not change.
However, if 50ng/ml of IGF-1 is also present, the response to testosterone is easily detected, and the increased testosterone concentration stimulates protein synthesis, 25-57% higher than the value obtained with testosterone alone.
Results obtained with 10-1000nm testosterone concentration plus IGF-1 were compared with values obtained with 1nm testosterone concentration plus IGF-1, and these concentrations caused more significant increases, P< 0.05.
Illustrated position
The figure on the left above shows the protein synthesis response of the hypertrophic organism to IGF-1+ testosterone. With increasing IGF-1 concentration, protein synthesis increased in a dose-dependent manner. The figure on the right above shows the protein synthesis reaction with increasing testosterone concentration in the presence (•) or absence of (○) IGF-I (50 ng/mL).
This study clearly shows that there is an interaction between testosterone and IGF-1 that stimulates total protein synthesis in fibroblasts. If IGF-1 is not added, even if the testosterone concentration is increased to 1000nm, there is no effect on the protein synthesis response of these cells. If IGF-1 is added, even if the testosterone concentration is as low as 10nm, it will stimulate protein synthesis.
At the same time, the synergistic effect of testosterone and IGF-1 can also be seen by comparing the left and right figures in the accompanying figure: testosterone enhances the maximum effect that IGF-1 can obtain.
Therefore, in addition to increasing muscle, the anabolic effects of IGF-1 also help to improve the effect of testosterone, especially in androgenic tissues.

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Understand the benefits of IGF-1 from its medical value
The main purpose of IGF-1 used by Bodybuilders is to enhance anabolic action to build muscle, and in fact, IGF-1 has proven medical value for the treatment of a variety of diseases. We can also know IGF-1 benefits from its medical value.
Description of IGF-1 astersteroids.com/understand-t…
IGF-1, short for insulin-like growth factor 1, is very similar in molecular structure to insulin, is produced primarily in the liver, and has anabolic effects in adults.
In addition to acting as IGF-1, IGF-1 supplementation stimulates endogenous IGF-1 production in the corresponding tissues. IGF-1 has a growth-promoting effect on almost every cell, especially skeletal muscle, cartilage, bone, liver, kidney, nerve, skin, etc. It promotes cell enlargement and division, inhibits apoptosis and increases cellular protein synthesis, coordinating the metabolism of proteins, carbohydrates and fats.
Treatment of primary IGF-1 deficiency with IGF-1
The FDA approved the use of rhIGF-1(also known as Mecasermin) for the treatment of severe primary IGF-1 deficiency in 2023. At the same time, the FDA approved the use of an equal molar combination of IGF-1 and IGFBP-3 (also known as Mecasermin Rinfabate) for the treatment of IGF-1 deficiency. Because IGFBP-3 also carries IGF-1, the carrier IGFBP-3 is saturated with IGF-1 when IGF-1 is administered alone, and IGF-2 can be bypassed to bind to IGF-1 when an equimolar combination of IGF-1 and IGFBP-3 is used. Both of these combined modes can be used to treat growth disorders.
IGF-1 is used to treat muscle injuries
The patented drug PEG-IGF-1 is an analogue of IGF-1, which provides effective protection against muscle damage caused by targeted acute contractions. It is also used to treat and prevent neuromuscular disorders, especially amyotrophic lateral sclerosis.
IGF-1 for burns
In Phase II trials of IGF-1, the efficacy of IGF-1 in the treatment of severe burns in children was demonstrated and positive results were achieved at doses of 1-4mg/kg/day.
IGF-1 is used to treat osteopenia and osteoporosis
IGF-1 has been tested in patients with osteopenia and osteoporosis associated with anorexia nervosa and severe fractures at doses ranging from 30 µg to 1 mg/kg/ day for 2-9 months with positive results.
IGF-1 is a hormone that exists in almost all human tissues. It is mainly produced by GH stimulation, and it is also an autocrine hormone. In addition, supplementing exogenous IGF-1 can also stimulate the secretion of IGF-1 in body tissues.

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How does IGF-1 promote anabolic effects in bodybuilding
IGF-1, stimulated by GH, is synthesized and secreted in the liver, and is also produced in target tissues in both autocrine and paracrine modes. How does IGF-1 play its anabolic role?
IGF-1 works by binding to the IGF-1 receptor, and before binding to the IGF-1 receptor, IGF-1 is transported to various parts of the body via IGF-binding proteins. Before we can understand how IGF-1 plays an anabolic role, we need to understand the IGF-1 receptor and IGF-binding proteins.
What is the IGF-1 receptor?
The IGF-1 receptor is a protein that exists on the surface of human cells and is activated by the IGF-1 hormone, thereby exerting anabolic effects.
IGF-1, which stands for insulin-like growth factor 1, has a similar molecular structure to insulin and therefore also binds to insulin receptors. However, its binding affinity with IGF-1 receptor is much higher than that with insulin receptor, so IGF-1 mainly binds to IGF-1 receptor and produces corresponding effects.
What are IGF-binding proteins?
Igf-binding protein is also known as IGFBP. IGF-1 has been shown to bind and interact with all seven IGFBPs (IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, IGFBP7). In the human body, 99% of IGFs bind to a series of binding proteins and are then carried to various parts of the body to bind to IGF-1 receptors at various sites, thereby exerting their anabolic effects.
The availability of IGF-1 is regulated by IGFBP, and by binding to IGFBP, the half-life of IGF-1 can be extended from a few minutes to a few hours to function. Different IGFBPs can also guide IGF-1 to different tissues and bind to specific IGF-1 receptors, thereby exerting corresponding effects.
Anabolic effects of IGF-1
Almost all IGF-1 binding to IGFBP is transported to various parts of the body, binds to the corresponding IGF-1 receptors and plays anabolic roles, contributing to tissue growth and development, proliferation, lipid metabolism, pro-survival, anti-aging, anti-aging and anti-oxidation, and nerve and liver protection. The antioxidant effects of IGF-1 protect mitochondria from oxidative damage and increase ATP synthesis, providing the body with energy and motivation for exercise.

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The difference between IGF-1 and GH, which one is better?

GH, as a growth hormone, is the most well-known anabolic hormone. Mention GH, you must mention IGF-1, because GH is secreted in the body in the form of a pulse, so if you want to determine whether the level of growth hormone in a person's body is enough, it is necessary to determine the level of IGF-1. IGF-1 is mainly produced by secretory stimulation of GH, therefore, GH acts through IGF-1, and some GH also acts alone. Similarly, IGF-1 mediates the action of GH while having an independent effect independent of GH. The two work synergistically and separately.
With GH and without iGF-1
In a new form of dwarfism, patients have high serum GH values, but they are unable to produce IGF-1. Studies have shown that their GH receptor genes are missing or mutated, resulting in an inability to produce IGF-1 and reduced synthesis of several other IGF-binding proteins (IGFBP). In these patients, who were slightly shorter from birth than the healthy babies, bone maturation and organ growth were delayed throughout the single year. At the same time, the deficiency of IGF-1 can also lead to poor muscle development and weakness.
By knocking out the IGF-1 gene or GH receptor, it was confirmed in mice that growth and bone development were impaired, body size was reduced, and growth rate decreased when IGF-1 was lacking.
After treatment with IGF-1, the mean growth rate of patients increased from 3-4.7cm/year to 8.2-9.1cm/year.
Synergistic effect of IGF-1 and GH
GH stimulates bone growth by stimulating the liver to produce IGF-1, and IGF1 in turn promotes longitudinal bone growth in an endocrine manner.
IGF mediates most of the effects of GH on bone metabolism, promoting cartilage formation and increasing bone formation by regulating the function of differentiated osteoblasts.


How to choose IGF-1 compared with GH?
For the vast majority of people, especially bodybuilders, IGF-1 and GH are both anabolic and growth-promoting hormones that perform similar functions. In fact, as different hormones, they still have a lot of subtle differences. In addition to muscle gain, bone health is also important to bodybuilders, and if your own bone mass is not enough to withstand the stress caused by the muscle gained, the consequences can be disastrous. IGF-1 plays an important role in bone health, however, with age, IGF-1 levels in the body decrease year by year, and the bone response to IGF-1 gradually decreases, requiring higher doses of IGF-1 to achieve the same anabolic effects. This is an advantage of IGF-1. At the same time, compared with GH,IGF-1 takes effect faster and can play a role faster.

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Know Effects and benefits of peptides IGF-1
Through the medical value of IGF-1, we know that the role of IGF-1 includes promoting growth and development, inhibiting muscle atrophy, promoting muscle growth, and benefiting bone health. In addition to these effects, IGF-1 also has anti-aging, anti-oxidation, enhanced immunity, improved learning ability, and regulated lipid metabolism and carbohydrate metabolism.
IGF-1 and lipid metabolism
A study of eight GH-deficient subjects showed that IGF-1 administration increased lipid oxidation, energy expenditure, and insulin resistance. This effect is thought to be due to IGF-1 inhibiting insulin secretion, which leads to enhanced lipidolysis in adipose tissue and promotes muscle utilization of free fatty acids.
Although mature fat cells are not the target of IGF-1, high concentrations of IGF-1 promote the secretion of IGF-1 by fat cells, and IGF-1 is involved in lipid metabolism through its interaction with insulin receptors.
IGF-1 and carbohydrate metabolism
IGF-1 has a direct effect on muscle glucose uptake, and a large number of IGF-1 receptors are present in skeletal muscle.
IGF-1 promotes peripheral tissue glucose uptake by 4%-7% more than insulin.
Anti-inflammatory effects of IGF-1
The fat tissue of obese people produces pro-inflammatory cytokines that interfere with normal nutritional signaling, leading to metabolic syndrome. The anti-inflammatory effects of IGF-1 may protect tissues in chronic diseases such as obesity from the harmful effects of pro-inflammatory factors.
IGF-1 anti-aging
Long filling of telomeres in DNA has been shown to be an important factor in longevity, and levels of IGF-1 are associated with longer telomere length in healthy subjects of all ages and in older men.
Antioxidant
IGF-1 increases glutathione peroxidase, an important antioxidant enzyme that protects cells by preventing cell death and increasing antioxidant status. It produces antioxidant effects that protect mitochondria from oxidative damage and increase ATP synthesis, providing the body with energy and motivation for movement.
Bone mineral density
IGF-1 is a direct promoter of bone growth. In older women, higher levels of IGF-1 are associated with higher bone mineral density. The anabolic effects of IGF-1 also promote bone density, and more muscle mass requires greater bone strength to support it.
Neuroprotective effect of IGF-1
Circulating IGF-1 has important vascular protective properties. Since cerebrovascular changes have a clear role in cognitive decline, reduced IGF-1 levels in aging populations may lead to vascular complications that lead to cognitive dysfunction.

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Retatrutide dosage calculator: to know the right dosage of LY-3437943
As a newest weight loss peptide Retatrutide, also call LY-3437943, the use and the right dosage may be unfamiliar for us, today, we will talk about Retatrutide dosage calculator.
What is Retatrutide LY-3437943?
Retalutide, a new drug in development for the treatment of obesity, overweight, is a triple receptor agonist that activates the GLP-1 (glucagon-like peptide-1) receptor, the GIP (Glucose-dependent insulin stimulation) receptor, and the GCG (glucagon) receptor. Through these three receptors, Retatrutide acts to suppress appetite, delay food digestion, increase satiety, and reduce hunger, in addition to inhibiting fat production and increasing lipolysis by acting on GCG receptors, while preserving lean muscle mass. In the process, it generates energy for areas such as skeletal muscle, improving the user's exercise level.
How to use Retatrutide with the right dosage
There is no official Retatrutide dosage calculator information on the market, and we have to seek for its right dosage from clinical trials.
In trial, Retatrutide was administered at doses of 1mg, 4mg, 8mg and 12mg per week in obese and overweight people. After 4 weeks of use, the average body weight of the subjects decreased by 7.2%, 12.9%, 17.3% and 17.5%, respectively. In the placebo group, the decline was 1.6%. After 48 weeks of treatment, the mean weight loss was 8.7%, 17.1%, 22.8% and 24.2%, respectively, compared with 2.1% in the placebo group.
In trials, it is generally considered that if the weight loss is greater than 5%, the drug is considered to have a weight loss effect. We can see that a weekly dose of 1mg of Retatrutide can achieve weight loss of more than 5%. Therefore, we can choose a dose of 4mg per week according to our actual situation and needs, which is a moderate and safe dose. Of course, if you want to reduce your target weight faster, you can also choose a dose of 8mg per week, but the maximum dose per week should not exceed 12mg.
How to manage you initial dosage?
In the Retatrutide type 2 diabetes trial, the doses used were 0.5mg, 4mg, 8mg, and 12mg. The 4mg and 8mg weekly doses involve starting doses of 2mg and 4mg, respectively. So, is the initial dosage of 2mg good for weight loss or the initial dosage of 4mg good for weight loss?
In the trial, when the weekly dose was 4mg, the initial dose was 2mg, and the average weight loss after 36 weeks was 7.92%; When the initial dose was 4mg, the weight loss after 36 weeks was 10.37%. From this data, when the weekly dose is 4mg, choosing the starting dose of 4mg can work faster and achieve more weight loss.
When the weekly dose was 8mg and the initial dose was 2mg, the mean weight loss at 36 weeks was 16.81%; When the starting dose was 4mg, the average weight loss after 36 weeks was 16.34%. From this data, there was little difference in weight loss, but the larger starting dose did not show an advantage.
Retatrutide dosage review
According to the above analysis, if the weekly dose of 4mg of Retatrutide is selected, it is not necessary to start with a low dose, but directly start with a dose of 4mg. If you choose the dose of 8mg per week, you can start with the lowest dose of 2mg per week and slowly increase to 8mg. If a dose of 12mg per week is required, it should be used from the starting dose of 2mg.
And so on, if your weekly dose is 5mg, the starting dose can be either 5mg directly or 2.5mg. If your weekly dose is 10mg, the starting dose should be 2.5mg.

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Understanding Testosterone Prescription Limitations and Exploring Alternatives in Testosterone Replacement Therapy
Testosterone is a hormone that plays a key role in the development and maintenance of male reproductive tissue and secondary sexual characteristics. It also has important effects on a variety of biological functions, including muscle mass, bone density, red blood cell production, and mood regulation. Testosterone levels naturally decline with age and can also be affected by diseases and impairment of certain organ functions, which can lead to a variety of symptoms and health problems.
 The role of testosterone prescription.
Testosterone is prescribed primarily for the treatment of hypogonadism and as a hormone therapy for sex transition.
Hypogonadism is mainly due to a person's physical condition or advancing age, in which case a doctor may begin testosterone replacement therapy (TRT). This treatment helps relieve symptoms associated with low testosterone.
For individuals receiving sex-confirming hormone therapy, testosterone is used to induce physiological changes in masculinization. This is a fairly small group, and TRT is usually the only way most people get testosterone prescriptions.
However, the conditions for issuing TRTS are becoming stricter. In 2015, the FDA redefined the indications for TRT products, stating that testosterone replacement therapy products should be avoided in patients with testosterone deficiency who do not have related diseases or have testosterone deficiency due to aging. This change prevents patients with testosterone deficiency due to aging from getting testosterone replacement treatment products from their doctors.
Testosterone dispute
Because of the FDA review, there is data showing that TRT can increase cardiovascular risk. Therefore, the use of TRT should be cautious. Additional data showed that the probability of cardiovascular risk was similar between TRT and placebo. The increased cardiovascular risk associated with TRT may be related to the use of high doses.
Those who disagree also have experimental data showing that low testosterone levels can lead to death and coronary artery disease, and that testosterone supplementation can reduce mortality, myocardial infarction and stroke rates.
Today, testosterone prescribing practices vary from place to place, and you may come across places that are particularly strict, while others are relatively liberal. Subject to various restrictions, normal bodybuilder basically can not get testosterone from the hospital, so many people will get testosterone through various channels.

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The latest 2023 Testosterone TRAVERSE study: testosterone does not increase the occurrence of major cardiovascular events
Many years have passed since testosterone was discovered and prescribed, but like all drugs, there are indications and possible side effects. The FDA states that there may be cardiovascular-related side effects from testosterone use and requires manufacturers of testosterone therapies to conduct clinical trials to assess whether they are associated with an increased risk of cardiovascular events. That's how the five-year TRAVERSE study of 5,076 participants came to be.
What is TRAVERSE study?
5,246 patients were randomized, of which 5,204 were included in the full analysis population. Of the 5,204 patients, 2,601 were randomized to receive testosterone and 2,603 were randomized to receive placebo. The overall population included 2847 patients with cardiovascular disease and 2357 patients with higher cardiovascular risk. They all reported hypogonadism and fasting testosterone levels below 300ng/dL on two occasions.
The dose is adjusted to maintain testosterone levels between 350 and 750ng/dL.
Mean duration of treatment: 21, 7+/-14.1 months
The mean follow-up time was 33.0+/-12.1 months
TRAVERSE study results
A major cardiovascular end point event occurred in 182 patients (7%) in the testosterone group and 190 patients (7.3%) in the placebo group.
The incidence of secondary endpoint events or composite primary cardiovascular endpoint events appeared to be similar in both groups. Higher rates of atrial fibrillation, acute kidney injury, and pulmonary embolism were observed in the testosterone group.
Atrial fibrillation: 3.5% in the testosterone group and 2.4% in the placebo group
Acute kidney injury: 2.3% in the testosterone group and 1.5% in the placebo group
Pulmonary embolism: 3.5% in the testosterone and 2.4% in the placebo group
What does the TRAVERSE study say?
TRAVERSE is the largest and longest-running testosterone study ever conducted. With its large sample size and duration of treatment, in addition to verifying cardiovascular problems, it also has many aspects to evaluate the improvement of sexual function, depressive symptoms, anemia and other symptoms, and the impact of testosterone on the prostate.
The TRAVERSE study showed no greater effect on major cardiovascular events than the placebo group. For these men with low testosterone levels, testosterone is safe from a cardiovascular standpoint alone. However, this does not mean that testosterone is completely free of side effects. Before using testosterone, adjust the dosage in time according to the doctor's guidance, and pay attention to its impact on the body.

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Safeguarding Health: Precautions for Testosterone and AAS Injections
Testosterone can be administered in a variety of ways, but the main way it is administered is by injection. Other AAS are mainly used by injection, but there are some that can be used orally.
Common injection sites are the buttocks, thighs, or upper arms. Users should use a new needle for each injection and disinfect the injection site prior to injection. Some users may experience pain at the injection site, which is usually temporary and goes away within a day or two. If needed, apply a cold compress to the injection site. It is best to choose a different site for injection each time, so as not to form scar tissue or cause excessive local hormones.
Steroid testosterone injection is in the muscle and should be avoided when injected into blood vessels. Suction before injection is important to confirm whether the needle is inserted into the blood vessel. Suction is the plunger that pulls the syringe back after the needle is inserted into the muscle. If blood is found in the syringe at this time, it means that you have hit a blood vessel and need to change the injection site.
If testosterone or AAS is injected into the bloodstream, it can cause a number of problems. The most serious problem is the increased risk of heart attack or stroke. This is because injected testosterone or AAS liquid can thicken the blood and cause arteries to block.
Only when testosterone or AAS is injected into the muscle can it be guaranteed to bind to the receptors in the muscle and promote muscle growth. If testosterone or AAS is injected into subcutaneous fat, it is absorbed more slowly by the body, affecting the effectiveness of use.
Injecting testosterone into the wrong place can also have serious health consequences, because testosterone affects brain chemistry.
In general, inject AAS such as testosterone with less care and make sure the hormone is injected into the muscle tissue.
AAS, such as testosterone for injection, are basically stored in oil-based carriers and released slowly into muscles to play their role. Appropriate needle sizes are needed, as these oily, high-viscosity preparations can be difficult to extract from small bottles. The No. 23 1-inch and No. 25 1-inch needles are standard for oil-based AAS such as testosterone. The smaller size of the needle helps reduce the likelihood of tissue scarring from long-term injections. A needle larger than 25 size can be used, but it may take longer to extract and inject an oil-based solution.

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The relationship between two IGF-1 analogs, IGF-1 LR3 and des(1-3)IGF-1
IGF-1 is a naturally occurring anabolic hormone, and growth hormone (HGH) also acts through IGF-1. The two commonly used hormones associated with IGF-1 are IGF-1 LR3 and des(1-3)IGF-1, and to understand the relationship between these three, we also need to understand another hormone associated with IGF-1, IGFBP.
IGF-1
IGF-1, short for insulin-like growth factor 1, also known as growth regulator C, is a hormone with a molecular structure similar to insulin.
IGF-1 is a protein encoded by the IGF1 gene in humans. IGF-1 consists of 70 amino acids on a single chain. It is produced primarily by the liver as an endocrine hormone and is produced in target tissues in a paracrine/autocrine manner.
IGF-1 has been shown to bind and interact with all seven IGF-1 binding proteins (IGFBP) : IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6, and IGFBP7.
Here comes IGFBP, which has a high binding affinity with IGF-1 and IGF-2, which prevents IGF-1 from binding to the IGF-1 receptor and functioning. IGFBP is naturally occurring in the body and greatly affects the potency of GIF-1. This is about one of the main reasons for the emergence of IGF-1 LR3 and des(1-3)IGF-1.
IGF-1 LR3
Also known as long arginine 3-IGF-1 or LR3-IGF-1. Is a synthetic protein due to the lengthening analogue of IGF-1.
Elimination half-life: 56-72 hours
Cas:143045-27-6
MF:C400H625N111O115S9
MW: 9117.60
It differs from natural IGF-1 in that it has arginine instead of glutamate in the third position of its amino acid sequence, and also has an additional 13 amino acids in the amino acid sequence. N-terminal, a total of 83 amino acids (IGF-1 is 70). The result of these modifications is that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an IGF-1 receptor hormone agent, has a very low affinity for insulin-like growth factor binding protein (IGFBP), and improves metabolic stability.
As a result, IGF-1 LR3 is about three times more potent than IGF-1 and has a significantly longer half-life of about 20-30 hours (IGF-1 has a half-life of about 12-15 hours).
DES(1-3)IGF-1
It is a naturally occurring endogenous protein and a truncated analogue of drugs and IGF-1. Des(1-3)IGF-1 lacks the first 3 amino acids of the IGF-1N terminal (67 amino acids in total, compared to 70 amino acids of IGF-1). Because of this difference, it greatly reduces binding to IGFBP and increases potency (in vivo about 10 to IGF-1).
Cas:112603-35-7
MF:C319H501N91O96S7
MW: 7371.48
As can be seen from IGF-1 LR3 and des(1-3)IGF-1, both were developed primarily to reduce their binding to IGFBP and thus increase their potency. So we often see the sale of IGF-1 LR3 and des(1-3)IGF-1 peptides, but we rarely see direct IGF-1.

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Under what circumstances I can not get prescription testosterone?
With the increase of age, natural testosterone levels will gradually decline, and will have a certain impact on the body, supplementing exogenous testosterone will promote the health of the body. However, testosterone is available by prescription. Can I get a prescription for testosterone?
Whether you can get a testosterone prescription, you first need to measure whether your testosterone level is lower than normal. If the test results show that your testosterone levels are in the normal range, a healthcare professional will generally not prescribe testosterone or AAS. Only patients who have been clinically diagnosed with lower than normal testosterone levels, or who have been diagnosed with hypogonadism, may receive external testosterone.
However, a diagnosis of a lower than normal level of testosterone does not necessarily require a prescription of testosterone. If you test for low testosterone but do not show symptoms associated with low testosterone, a healthcare professional may not prescribe you testosterone. Typically, prescription testosterone is only given if a patient is diagnosed with lower than normal levels of testosterone, along with symptoms of low testosterone, including fatigue, decreased libido, mood changes, muscle wasting, and more.
Other patients may have low testosterone levels, but their physical health does not support their use of prescribed testosterone. For people with prostate cancer, breast cancer, serious heart disease, liver disease, or uncontrolled sleep apnea, prescription testosterone is risky, cannot be used, or requires special precautions to use prescription testosterone.
A natural decrease in testosterone levels, such as that commonly seen with age, is in most cases not enough to affect the health of the body to obtain a testosterone prescription. However, in this case, sub-health will always exist, you may appear fat, tired, muscle mass can not maintain the situation. If bodybuilders are in this situation, it will be very difficult to gain muscle mass, i.e. gain muscle, and it will be very difficult to retain it. At the same time, there will be an increase in fat mass, and it is difficult to lose fat.
Supplementation with exogenous testosterone or AAS is the most direct way to improve these symptoms, however, it is difficult to get prescription testosterone from your doctor. Some people buy testosterone or AAS from other sources, however, these sources are usually unregulated, and you can't guarantee that what you're buying is genuine.

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DHEA: Understanding its Role and Conversion to Testosterone
Dehydroepiandrosterone (DHEA) is a hormone that occurs naturally in the body and is produced primarily by the adrenal glands. It is a precursor to several other hormones, including testosterone. The conversion of DHEA to testosterone is a key process that affects various physiological functions in both men and women. Many people think that using DHEA can replace the effects of testosterone, right?
What is DHEA?
Dhea is classified as a steroid hormone and is the most abundant hormone in the human body. It plays an important role in many physiological processes, including metabolism, immune function, and sexual health. Although DHEA is produced primarily by the adrenal glands, it is also synthesized in the brain, ovaries, and testes.
Once synthesized, dehydroandrosterone circulates in the blood in an inactive form called dehydroepiandrosterone sulfate (DHEAS). It is then converted back to its active form, DHEA, by the action of the enzyme sulfase. This conversion occurs primarily in the target tissues of DHEA, such as the gonads and brain.
How is DHEA converted to testosterone?
One important way in which DHEA functions is through its conversion to testosterone. Testosterone is an important hormone for both men and women, affecting aspects of sexual development, muscle growth, and bone density. With the help of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSDS), the conversion of DHEA to testosterone occurs primarily in the gonads.
The conversion of DHEA to testosterone requires a series of enzymatic reactions. First, DHEA is converted to androstenedione by the action of 3β-hydroxysteroid dehydrogenase (3β-HSD). Androstenedione is a weak androgen that can be further converted into testosterone.
The final step in the conversion process is facilitated by the enzyme 17β-HSD, which converts androstenedione into testosterone. This step is essential for maintaining proper testosterone levels in the body
use DHEA is better than use testosterone directly?
In contrast to direct testosterone supplementation, which may inhibit endogenous testosterone secretion, DHEA, as a precursor of testosterone, indirectly increases testosterone levels. It sounds like using DHEA is better than using testosterone directly, but is it?
DHEA is a natural precursor hormone produced by the human body, and the use of DHEA can support a natural increase in testosterone levels rather than directly introducing exogenous testosterone. It should be relatively safer. However, as the article wrote earlier, the conversion of DHEA to testosterone occurs through an enzymatic reaction. In practice, this conversion is affected by many factors and is not 100% effective. The body regulates its own hormone levels and does not allow any one hormone to increase indefinitely. Therefore, excess DHEA may not lead to a proportional increase in testosterone levels.
The use of DHEA has a broader impact, playing a role in a variety of physiological functions, including metabolism, immune function, and brain health, among others, so it is more useful for people seeking hormonal balance and overall health. For users who have low levels of testosterone themselves or who aim to gain muscle or strength, testosterone use will be more directly effective.

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Exploring FDA-Approved Testosterone Injections: A Comprehensive Review
There are three FDA-approved testosterone formulations for use: TC (Test Cypionate),TE (Test Enanthate), and TU (Test undecanoate). They are both testosterone and have different half-lives because they are attached to ester chains of different lengths. TU has the longest ester chain, consisting of 11 carbon atoms, so it has the longest half-life and lasts longer after injection. TC and TE are composed of 7 and 8 carbon atoms, respectively.
This article provides an in-depth overview of the FDA-approved testosterone injection options, their benefits, and considerations for individuals.
TC
TC finished steroid is one of the most commonly used testosterone injections. This is a long-acting preparation that delivers testosterone slowly into the bloodstream. This reduces the frequency of injections, which are usually given every 1-2 weeks. Effective results have been shown in increasing testosterone levels and addressing symptoms associated with low testosterone.
TC is generally available in two different concentrations, 100mg/ml and 200mg/ml, dissolved in cottonseed oil.
The clinically recommended dose for testosterone therapy is 75mg-100mg intramuscular injection weekly or 150-200mg intramuscular injection every two weeks. One study of TC 200mg administration in hypogonadal males,
TE
TE is another FDA-approved testosterone injection. It is similar to TC in terms of duration of action and frequency of administration.
The common concentration of TE is 200mg/ml and is formulated with sesame oil.
TU
TU is a unique testosterone injection formulation that utilizes long-acting esters, which are used less frequently than TC and TE, and this long-acting testosterone provides convenience for those who do not prefer frequent injections.
TU is formulated with a concentration of 250mg/ml and is prepared from refined castor oil. The recommended dose is 750Mg intramuscularly every 4 weeks and, after 8 weeks, 750mg every 10 weeks.
Choose the right testosterone Injection
TC, TE and TU are three types of testosterone injection, each with its own unique characteristics and frequency of administration, users can choose their own testosterone Injection based on personal factors, lifestyle, medical history and preferences.
In addition to treating hypogonadism, these testosterone injections can increase energy levels, improve sexual function, increase muscle mass, and improve mood and health. However, possible side effects should also be considered during use, including acne, fluid retention, and potential effects on prostate health. Timely guidance from healthcare providers is essential to ensure the safe use of testosterone injection.

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Testosterone's Dual Power: Unraveling its Role in Muscle Growth and Fat Reduction
If we don't know exactly what testosterone does, we can easily name a few. If you ask how testosterone works, most people probably don't know. Today, we will take a brief look at it.
What's the use of that, you might say? Who knows, maybe one day you'll need it, maybe someone just needs the knowledge.
The action of testosterone is through a combination of many different pathways, at the cellular and organ level, the action of testosterone does not depend on genomic mechanisms, most of the action is through the binding of hormone receptors. Bound androgen receptors act as transcriptional regulatory elements by binding to specific DNA response elements in target gene promoters, causing activation or inhibition of transcription and subsequent protein synthesis.
Effects on muscle mass and strength
The effects of testosterone on muscle mass and strength occur primarily through binding to androgen receptors. The degree to which it works is positively correlated with the dose used, and if the dose used is too low, it may not have any effect.
A study giving testosterone enanthate 200mg every 2 weeks found that an increase in mass was observed after 12 weeks, with the greatest effect achieved after 6-12 months. This is a very small dose at which improvements in muscle mass and strength are observed.
Effect on bone mineral density
The effect of testosterone on bone mineral density is mediated by estrogen, which acts on testosterone derivatives produced after the interaction of testosterone with aromatase.
In the study, testosterone continued to improve lumbar bone mineral density from 6 months to 36 months.
Effect on lipids
Testosterone plays an important role in obesity, glucose homeostasis and lipid metabolism. It promotes myogenic differentiation of mesenchymal pluripotent cells through androgen receptor-mediated pathway and inhibits their differentiation into fat. After using testosterone, fat mass will decrease and lean body mass will increase. There is no significant change in total weight at the beginning, and in general, total mass begins to increase after 3 months.
Testosterone induces changes in lipid metabolism and changes in insulin signaling after the receptors in the muscles as well as an increase in insulin sensitivity, resulting in a decrease in total cholesterol levels and triglyceride levels.
Testosterone treatment also has a variety of effects such as lowering blood pressure, promoting cardiovascular health, reducing inflammation, and promoting sexual desire, affecting many parts of the body as well as physical and mental health.

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Unveiling the Truth: Can Exogenous Testosterone Truly Replicate Natural Testosterone's Effects?

Natural testosterone refers to the testosterone naturally secreted by the body, which is mainly produced by the testicles and is regulated by positive and negative feedback of HPTA.
Exogenous testosterone refers to testosterone introduced into the body from the outside, including testosterone replacement therapy (TRT) or anabolic steroids (AAS).
Exogenous testosterone plays a role similar to natural testosterone, but it does not completely replace the role of natural testosterone.
When exogenous testosterone is introduced, it can increase overall testosterone levels, which brings various benefits such as improving the body's anabolism, increasing muscle mass, strength, and improved athletic performance. It can also relieve symptoms associated with low testosterone, such as fatigue, decreased libido, and mood changes.
However, exogenous testosterone does not fully replicate the complex hormone levels and regulation provided by naturally produced testosterone in the body. The body's naturally produced testosterone is subject to complex feedback loops and hormonal interactions that cannot be replicated by external testosterone management alone.

Exogenous Testosterone vs Natural Testosterone
Natural testosterone is continuously secreted into the circulatory system by testicular endocrine cells, and the concentration fluctuates little, showing a circadian rhythm. Exogenous testosterone is released by a one-time injection or orally, which can cause significant fluctuations in serum testosterone levels. Because of the different ways in which they are released, the ways in which exogenous testosterone and its metabolites bind to testosterone receptors also differ.
Natural testosterone interacts with aromatase or 5AR in the body to produce testosterone metabolites, and corresponding actions also occur in the body. Some exogenous testosterone is derived from testosterone, but the structure will change, and when it does not interact with aromatase or 5AR, it will also bring corresponding side effects.
Exogenous testosterone levels are not controlled by the endocrine system, and excessive use or absence of medical supervision during use can cause side effects including hormonal imbalance, cardiovascular, mood, and inhibition of natural testosterone production.

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Testosterone forms when using for medical
Since its discovery and in-depth study by biologists, testosterone has provided many new directions for human health and disease treatment. When testosterone is used for medical purposes, it usually comes in the form of exogenous testosterone, which is used to supplement or replace the body's naturally produced testosterone and has an irreplaceable role. There are various forms of medical testosterone available, and This blog will begin with a few forms when using testosterone for medical purposes.
Take orally
Oral testosterone is easy to use, but it is metabolized by the liver and has low bioavailability, so oral testosterone is not widely used. The orally available testosterone is testosterone undecanoate (TU). The alkylation of testosterone on C17α produces testosterone derivatives with the ability to bypass first-pass metabolism, but with certain hepatotoxicity, such as methyltestosterone
Injection
Intramuscular injections are the most common form of testosterone use. Common ones are to test cypionate and test enanthate, which allow for the slow release of testosterone into the bloodstream, providing stable testosterone levels for 1-4 weeks.
Topical gels and creams
These include 1% and 2% testosterone gels applied daily to the skin and absorbed through the bloodstream. The testosterone levels they provide are fluctuating, but they are more convenient to use and provide a convenient option for testosterone supplementation.
Testosterone patch
These drug patches are placed on the skin and deliver a certain amount of testosterone into the bloodstream. They are usually attached to the arms or upper body and sustainably release testosterone. Change every 24-72 hours depending on the specific patch.
Testosterone pellets
During minor surgery, subcutaneous pellets are surgically implanted. This small pill slowly releases testosterone over a period of 3-6 months, providing long-lasting effects. It was the first effective formulation developed in the 1940s.
Testosterone in the oral system
Oral dosing was originally approved by the FDA in 2003. This use delivers testosterone directly to the systemic circulation and bypasses the liver, avoiding first-pass metabolism and improving bioavailability.
This involves placing a testosterone tablet between the cheek and gums and slowly releasing testosterone into the body. It needs to be changed twice a day.
Low testosterone levels are associated with a shorter life span and an increased risk of many diseases, as well as sexual dysfunction, muscle and bone degradation, out-of-shape shape, metabolic disorders, and decreased immunity, endangering physical and mental health. Fortunately, with the development of science and technology, and the in-depth study of testosterone and its derivatives, the phenomenon of low testosterone can be well solved.
For bodybuilder, low testosterone levels are not conducive to muscle growth and maintenance and do not take advantage of bone health. In general, if bodybuilder does not increase their own testosterone levels, it is difficult to gain weight.
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